PMID: 8678686Jul 1, 1996Paper

Non-heart-beating donors: a model of thoracic allograft injury

The Annals of Thoracic Surgery
M C MauneyC G Tribble

Abstract

4ACKGROUND. Non-heart-beating donors (NHBDs) have been proposed for the critical shortage of donors for cardiac and pulmonary transplantation. We determined the effects of prearrest hypoxia and postarrest warm ischemia on cardiac and pulmonary allografts procured from NHBDs undergoing hypoxic arrest. METHODS. Rabbit hearts and lungs were procured from separate donors and placed on isolated blood perfusion circuits. Controls were excised and perfused without ischemia. Heart from NHBDs underwent either prearrest hypoxic perfusion alone or consecutive periods of prearrest hypoxic perfusion and 20 minutes of postarrest warm ischemia. A third group of hearts underwent 30 minutes of warm, global ischemia alone. Two groups of pulmonary allografts were studied using similar hypoxic perfusion/20-minute ischemia and 30-minute ischemia donors. RESULTS. Prearrest hypoxic perfusion clearly causes significant dysfunction of cardiac allografts from NHBDs compared with nonischemic controls. Prearrest hypoxic perfusion combined with postarrest ischemia results in an additive degree of dysfunction more severe than a similar period of warm ischemia alone. Both groups of experimental lungs displayed function similar to that of nonischemic controls...Continue Reading

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Citations

Nov 14, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Makoto MohriShunji Sano
Dec 6, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Christopher James Doig, Graeme Rocker
Jun 1, 1997·The Annals of Thoracic Surgery·J T CopeC G Tribble
Jan 22, 1998·The Annals of Thoracic Surgery·J T CopeI L Kron
Oct 13, 1998·The Annals of Thoracic Surgery·P E ParrinoI L Kron
Aug 1, 1997·Transplantation Proceedings·O DetryF E Sluse
Mar 20, 1999·Transplantation Proceedings·A M ScheuleG Ziemer
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Albertus M ScheuleGerhard Ziemer
Nov 1, 1996·The Annals of Thoracic Surgery·J T CopeC G Tribble
Feb 21, 2003·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Jane M Braverman
Apr 19, 2019·Circulation. Heart Failure·Petra NiederbergerSarah L Longnus

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