PMID: 51796Jun 1, 1975Paper

Non-helical sequences of rabbit collagen. Correlation with antigenic determinants detected by rabbit antibodies in homologous regions of rat and calf collagen

European Journal of Biochemistry
U BeckerR Timpl

Abstract

Non-helical peptide fragments were isolated from rabbit skin collagen after cleavage of alpha chains with cyanogen bromide and proteases. Determination of their amino acid sequence indicated a length of 9, 16 and 25 amino acid residues for the non-helical sequences located in the N-terminal region of alpha2 and alpha1 chain and in the C-terminal region of alpha1 chain, respectively. The C-terminal sequence Tyr-Tyr hitherto considered as the genuine end of collagen alpha1 chain is in part of rabbit collagen extended by two residues, alanine and arginine. Rabbit collagen may differ considerably in its non-helical sequences from other vertebrate collagens, particularly in the C-terminal part. Some but not all of these differences are clustered in areas occupied by antigenic determinants which are recognized in the antibody response of rabbits to rat or calf collagen. On the other hand, a high homology to rabbit collagen, e.g. in the N-terminal region of rat collagen alpha1 chain or calf collagen alpha2 chain, probably prevents immunological recognition by the rabbit. The degree of foreignness alone, however, may not necessarily determine whether a particular non-helical area is able to express immunogenic activity.

References

May 6, 1975·Biochemistry·N R DavisG A Pringle
Jan 1, 1975·International Archives of Allergy and Applied Immunology·G WickR Timpl
Jun 1, 1971·The Journal of Experimental Medicine·H LindsleyP Bornstein
Jan 1, 1971·Advances in Protein Chemistry·W Traub, K A Piez
May 26, 1972·Biochemical and Biophysical Research Communications·H Furthymayr, R Timpl
May 23, 1972·European Journal of Biochemistry·J RauterbergH Furthmayr
Oct 17, 1972·European Journal of Biochemistry·P P FietzekK Kühn
Jan 1, 1974·Contemporary Topics in Immunobiology·R K Gershon
Oct 9, 1974·Biochimica Et Biophysica Acta·P P FietzekK Kühn
Oct 1, 1972·FEBS Letters·M StolzK Kühn
Aug 7, 1972·Biochemical and Biophysical Research Communications·D R Eyre, M J Glimcher
Oct 15, 1972·FEBS Letters·U Becker, R Timpl

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Citations

Nov 1, 1980·Journal of Clinical Pathology·H K BeardC L Greenbury
Nov 10, 2009·Cell and Tissue Research·Klaus von der MarkPatrik Schmuki
Feb 1, 1995·Annals of the Rheumatic Diseases·G Bou-GhariosI Olsen
Nov 9, 1982·Biochimica Et Biophysica Acta·P F Davison, M Brennan

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