Non-hepatocellular carcinoma spinal metastases

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
C Rory GoodwinDaniel M Sciubba

Abstract

Metastases to the spine from non-hepatocellular carcinomas, such as cholangiocarcinoma and angiosarcoma, occur rarely. With improvements in oncologic care, the number of patients diagnosed with metastatic cancer is expected to increase. We performed a systematic review of the literature to assess the clinical presentation, treatment, outcome and survival of patients diagnosed with non-hepatocellular carcinoma spinal metastasis using PubMed, Embase, CINAHL, Cochrane Library and Web of Science. We identified 19 cases of spinal metastases from non-hepatocellular carcinomas that fit our pre-specified criteria. The mean age at presentation was 62.3years and cholangiocarcinoma was the most common subtype. Patients frequently presented with pain, weakness or paraparesis and at the time of diagnosis, most of them had multi-level involvement of the spine. A majority of patients with spinal metastasis were treated either with radiation or chemotherapy or received no treatment. A minority of the reports included information on survival, which revealed a median survival of 1.5months following diagnosis of the spinal metastasis. Although there is a paucity of published literature on non-hepatocellular carcinoma spinal metastasis, this syste...Continue Reading

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Citations

Jan 22, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Pawalee DowsirirojPolasak Jeeravipoolvarn
Mar 30, 2018·Clinical Spine Surgery : a Spine Publication·Apiruk SangsinHideki Murakami
Sep 17, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sho DohzonoHiroaki Nakamura

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