Non-hexameric DNA helicases and translocases: mechanisms and regulation.

Nature Reviews. Molecular Cell Biology
Timothy M LohmanColin G Wu

Abstract

Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling. Fuelled by the binding and hydrolysis of nucleoside triphosphates, helicases move along nucleic acid filaments and separate double-stranded DNA into their complementary single strands. Recent evidence indicates that the ability to simply translocate along single-stranded DNA is, in many cases, insufficient for helicase activity. For some of these enzymes, self assembly and/or interactions with accessory proteins seem to regulate their translocase and helicase activities.

References

Jun 1, 1976·European Journal of Biochemistry·M Abdel-Monem, H Hoffmann-Berling
Jun 1, 1976·European Journal of Biochemistry·M Abdel-MonemH Hoffmann-Berling
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J F ScottA Kornberg
Sep 15, 1977·European Journal of Biochemistry·M Abdel-MonemH Hoffmann-Berling
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G T Yarranton, M L Gefter
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·M DuguetM Gefter
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S EisenbergA Kornberg
Jan 1, 1992·Molecular Microbiology·T M Lohman
Oct 20, 1991·Journal of Molecular Biology·K L Chao, T M Lohman
Jan 1, 1991·Progress in Nucleic Acid Research and Molecular Biology·S W Matson
Jan 1, 1981·Annual Review of Biochemistry·K Geider, H Hoffmann-Berling
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T L Hill, T Tsuchiya
Jul 13, 1993·Biochemistry·M Amaratunga, T M Lohman
Apr 1, 1996·Nucleic Acids Research·A K EgglestonS C Kowalczykowski
Jan 1, 1996·Annual Review of Biochemistry·T M Lohman, K P Bjornson
Nov 28, 1996·Nature·H S SubramanyaD B Wigley
Jun 1, 1997·Nature Structural Biology·N YaoP C Weber
Jun 1, 1997·Current Opinion in Genetics & Development·N A Ellis
Nov 22, 1997·Journal of Molecular Biology·J A Farah, G R Smith
Apr 23, 1999·The Journal of Biological Chemistry·L E MechanicS W Matson
Nov 2, 1999·Journal of Molecular Biology·J A AliT M Lohman
Dec 14, 1999·Molecular Microbiology·M C Hall, S W Matson
Jun 1, 2000·Nature·P R Bianco, S C Kowalczykowski
Aug 31, 2000·Annual Review of Biochemistry·S S Patel, K M Picha
Feb 13, 2001·Trends in Biochemical Sciences·P Soultanas, D B Wigley
Jun 29, 2001·Journal of Molecular Biology·W ChengT M Lohman
Oct 12, 2001·Cell·M R SingletonD B Wigley
Nov 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bindu NanduriKevin D Raney
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Wei ChengTimothy M Lohman
Jan 16, 2003·Journal of Molecular Biology·Nasib K MalufTimothy M Lohman
Mar 28, 2003·The Journal of Biological Chemistry·Mikhail K LevinSmita S Patel
May 16, 2003·Nature·Lumir KrejciPatrick Sung

❮ Previous
Next ❯

Citations

Aug 5, 2010·Quarterly Reviews of Biophysics·Jaya G YodhTaekjip Ha
Jul 29, 2011·Biochemistry·Anita Niedziela-MajkaTimothy M Lohman
Dec 24, 2011·Biochemistry·Jenny R ChangCarlos E Catalano
Aug 25, 2012·Biochemistry·Veronica M RaneyKevin D Raney
May 23, 2013·Nature Communications·Kyung Suk LeeTaekjip Ha
Mar 20, 2010·Physical Chemistry Chemical Physics : PCCP·Yann R Chemla
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Arnon HennEnrique M De La Cruz
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Timur Yusufzai, James T Kadonaga
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Behzad Rad, Stephen C Kowalczykowski
Apr 7, 2010·The Journal of Biological Chemistry·Vaishnavi RajagopalSmita S Patel
Jul 17, 2012·The Journal of Biological Chemistry·Dustin W AlbrechtScott W Nelson
Jan 9, 2009·The Journal of Biological Chemistry·Joseph T P YeelesMark S Dillingham
May 12, 2010·The Journal of Biological Chemistry·Kevin D RaneyCraig E Cameron
Feb 1, 2011·Journal of Molecular Cell Biology·Xincheng LuGuangbin Luo
Oct 27, 2009·Nucleic Acids Research·James E GrahamLidia K Arciszewska
Jan 31, 2012·Nucleic Acids Research·Yuliang Wu, Robert M Brosh
Jan 1, 2013·Nucleic Acids Research·Francesca FioriniHervé Le Hir
Feb 26, 2013·Nucleic Acids Research·Io Nam WongCyril M Sanders
Mar 1, 2013·Nucleic Acids Research·Roberto Galletto, Eric J Tomko
Oct 17, 2008·Genes & Development·Serge GravelStephen P Jackson
Sep 22, 2009·Journal of Bacteriology·Marta V SutEllen L Zechner
Mar 3, 2010·Annual Review of Biophysics·Wei Yang
Jan 23, 2009·BMC Structural Biology·Takuji OyamaKosuke Morikawa
May 23, 2012·PloS One·Adeyemi O AdedejiStefan G Sarafianos
Aug 8, 2012·PloS One·Sabine Matallana-SurgetPhilippe Lebaron
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Alicia K Byrd, Kevin D Raney
Mar 13, 2012·Annual Review of Biophysics·Taekjip HaTimothy M Lohman
Mar 13, 2012·Annual Review of Biophysics·Arnon HennEnrique M De La Cruz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.