Non-high-density lipoprotein cholesterol: current status as cardiovascular marker

Current Opinion in Lipidology
Rutger VerbeekS Matthijs Boekholdt

Abstract

In this review, we summarize the evidence with regard to the rationale of using nonhigh density lipoprotein cholesterol (non-HDL-C) as a cardiovascular disease (CVD) risk factor, in relation to low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB). In the 2015 National Lipid Association Annual Summary non-HDL-C is considered a coprimary target, apart from LDL-C. The other data published in the last 18 months about non-HDL-C support all the previous published data. There are no recent findings, which we deem to cause a change of the current opinion about non-HDL-C as a predictor for CVD. The existing evidence supports the claim that non-HDL-C is superior to LDL-C in CVD risk estimation.

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Citations

May 13, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hongtao LiuXuedong Yu
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Charlotte KoopalFrank L J Visseren
Nov 24, 2017·Npj Aging and Mechanisms of Disease·Irene AlfarasRafael de Cabo
Nov 15, 2018·European Journal of Preventive Cardiology·Barak ZafrirErez Sharoni
Apr 20, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J WuX Zhao
Aug 1, 2019·The Journal of Clinical Endocrinology and Metabolism·James L RosenzweigBruno L Vergès
Jul 18, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Walter MassonJuan Patricio Nogueira
Mar 13, 2021·BMC Cardiovascular Disorders·Paul Pettersson-PabloAnita Hurtig-Wennlöf
Dec 15, 2020·Medicine and Science in Sports and Exercise·Heather L PetrickJamie F Burr
Jul 28, 2021·Journal of Clinical Lipidology·Jing YuFengxian Huang

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