PMID: 6166847Jun 9, 1981Paper

Non-histone chromatin proteins during various stages of activity of immunocompetent cells

Molecular and Cellular Biochemistry
A HorstE Wiland

Abstract

Qualitative and quantitative changes of non-histone chromatin proteins of spleen cells during the primary immune response to sheep red blood cells and aggregated human gamma-globulin were described. Synthesis of non-histone chromatin proteins was measured by labelling with 3H-tryptophan during culture of spleen cells in vitro. Chromatin was isolated and labelled proteins were analysed by polyacrylamide gel electrophoresis. During the immune response to both antigens in chromatin of spleen cells three new fractions of non-histone chromatin proteins were synthesized: fractions F1 - M = 12 000 and H - M = 3 000, specific for sheep red blood cells and fractions I1 - M less than 3 000 and B - M = 120 000, specific for human gamma-globulin. The third antigen-non-specific fraction was synthesized at the time when the primary immune reaction was finishing. These new fractions were synthesized only in one of the analysed subpopulations of spleen cells. In thymocytes (non-fully-differentiated lymphoid cells) all these fractions were absent. Changes of non-histone chromatin proteins in thymocytes during the immune response were similar to those found during stimulation to proliferation by phytohemagglutinin in vitro.

References

Dec 21, 1978·Biochimica Et Biophysica Acta·D I Stott, A R Williamson
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F KeppelH Eisen
Dec 21, 1978·Biochimica Et Biophysica Acta·D I Stott, A R Williamson
Sep 1, 1973·Archives of Biochemistry and Biophysics·L H Augenlicht, R Baserga
Jul 27, 1973·Biochimica Et Biophysica Acta·T C SpelsbergB W O'Malley
May 18, 1972·Biochimica Et Biophysica Acta·M Yoshida, K Shimura

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Citations

Jan 1, 1985·Molecular and Cellular Biochemistry·B SiemieniakoA Horst
Nov 26, 1982·Molecular and Cellular Biochemistry·E M Rakowicz-Szulczyńska, A Horst
Jun 9, 1981·Molecular and Cellular Biochemistry·E M Rakowicz-Szulczyńska, A Horst
Jun 9, 1981·Molecular and Cellular Biochemistry·A Horst, E M Rakowicz-Szulczyńska
Dec 1, 1981·Mechanisms of Ageing and Development·Z A Medvedev
Aug 1, 1983·Molecular Immunology·J C Lincoln, D I Stott
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E M Rakowicz-SzulczynskaH Koprowski
Jan 15, 1990·Biochemical and Biophysical Research Communications·E WilandW H Trzeciak
Jan 1, 1985·Cell Biochemistry and Function·E M Rakowicz-Szulczyńska, A Horst
Oct 15, 1986·Biochemical and Biophysical Research Communications·E M Rakowicz-Szulczynska, H Koprowski

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