Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children - a series of case reports and a review of the literature (CARE compliant)

Medicine
Cristina Oana MărgineanMihaela Ioana Chinceşan

Abstract

Non-Hodgkin lymphoma remains an unpredictable condition in pediatric patients. Our first case describes an 8-year-old boy with a history of iron deficiency anemia, admitted in our clinic for recurrent abdominal pain, weight loss, loss of appetite, diarrheic stools, and fever. The second case also describes an 8-year-old boy admitted for abdominal pain and vomiting. The 3rd case refers to a 4 years and 10 months old boy admitted in our clinic with abdominal pain and loss of appetite, who was initially admitted in the Pediatrics Surgery Clinic with the suspicion of appendicitis. Our 4th patient was a 5-year-old boy admitted in our clinic for abdominal pain and intermittent diarrheic stools. In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia. The abdominal ultrasound and CT exam revealed an abdominal mass, and the histopathological exam established the diagnosis of diffuse large B-cell lymphoma of the bowel. In the second case, the laboratory tests pointed out anemia, elevated ESR and lactate dehydrogenase level, while both abdominal ultrasound and CT exams showed an abdominal mass. The histopathological exam confirmed the diagnosis of B...Continue Reading

References

May 9, 1996·The New England Journal of Medicine·J T SandlundW M Crist
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Sep 4, 2008·International Journal of Cancer. Journal International Du Cancer·Martin D OgwangSam M Mbulaiteye
Sep 11, 2008·Journal of the National Cancer Institute·Dianne PulteHermann Brenner
Mar 3, 2011·The American Journal of Tropical Medicine and Hygiene·Benjamin EmmanuelSam M Mbulaiteye
Jan 21, 2012·British Journal of Haematology·Rodney R MilesMitchell S Cairo
Jun 17, 2014·Infectious Agents and Cancer·Daniela C Stefan, Rabeen Lutchman
Jun 3, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Tugba KocaMustafa Akcam
Dec 1, 2013·Journal of Ultrasonography·Agnieszka BrodziszJerzy Kowalczyk
Jan 18, 2017·Adolescent Health, Medicine and Therapeutics·Massimo DozzoRenato Bassan

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Methods Mentioned

BETA
biopsy
ESR
surgical resection

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