Non-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency

European Journal of Pediatrics
Monica Piquer GibertMaria Anunciacion Martin-Mateos

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency associated with an increased risk of malignancy in adulthood, with lymphoma as one of the major causes of death. The aim of this study is to describe those malignancies detected in our cohort of pediatric CVID patients. We reviewed the clinical and laboratory data and the treatments and their outcomes in all pediatric CVID patients from our institution that developed a neoplasia. Four malignancies were diagnosed in three out of 27 pediatric CVID patients. Three malignancies were non-Hodgkin lymphoma (NHL) of B cell origin (mean age at diagnosis: 8 years old), and the remaining was a low-grade astrocytoma. Among NHL, two were mucosa-associated lymphoid tissue (MALT) lymphomas and one was associated with Epstein-Barr virus infection. NHL developed before CVID diagnosis in two patients. CVID patients showed different clinical phenotypes and belonged to different groups according Euroclass and Pediatric classification criteria. Malignancies, especially lymphoma, may develop in pediatric CVID patients with no previous signs of lymphoid hyperplasia and even before CVID diagnosis. Consequently, strategies for cancer prevention and/or early diagnosis ar...Continue Reading

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Citations

Feb 13, 2016·Indian Journal of Pediatrics·Biman Saikia, Sudhir Gupta
Feb 10, 2016·Current Allergy and Asthma Reports·Paul J Maglione
Apr 25, 2019·Reviews in Medical Virology·Timothy P W JonesDavid M Lowe
Aug 2, 2018·Journal of Thoracic Imaging·Tami J BangDavid A Lynch
Aug 28, 2019·Expert Review of Clinical Immunology·Fatemeh KiaeeAsghar Aghamohammadi
Apr 17, 2017·Allergologia et immunopathologia·A Tak ManeshA Aghamohammadi
Dec 24, 2021·European Journal of Pediatrics·Aleksandra Szczawinska-PoplonykMonika Wiczuk-Wiczewska

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