Non-Hodgkin's lymphoma in patients 70 years of age or older: factors associated with survival

Leukemia Research
Janet CuttnerKevin Troy

Abstract

The incidence of non-Hodgkin's lymphoma (NHL) has increased dramatically especially in persons over 60 years of age. We reviewed our experience in patients with NHL who were 70 years of age or older and seen between 1992 and 1998 in an effort to find any unique risk factors in this age group. There were 64 patients. Twenty-five had indolent disease and 38 had aggressive disease. The majority of patients with indolent lymphoma presented with nodal disease and were more likely to have bone marrow involvement. In contrast, 71% of patients with aggressive lymphoma presented with extra-nodal disease. Five of seven (71%) patients with indolent and 22 of 29 (76%) with aggressive NHL who received an Adriamycin containing regimen as first line therapy achieved a complete response. The International Prognostic Index (IPI) was a strong predictor of both survival (P<001) and response (P=007) for the group as a whole. The IPI accurately predicted the survival of patients with aggressive NHL (P=026). This was not the case with indolent lymphomas. This study suggests that elderly patients with NHL are more likely to have aggressive disease, a diffuse pathology and an extra-nodal presentation.

References

Dec 1, 1987·The American Journal of Medicine·P Solal-CelignyP Boivin
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project

❮ Previous
Next ❯

Citations

Mar 2, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O BaireyR Ruchlemer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

British Journal of Haematology
Gail L StarkNorthern Region Lymphoma Group
Annals of Oncology : Official Journal of the European Society for Medical Oncology
S J ProctorU Tirelli
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Elaine S JaffeH K Müller-Hermelink
© 2022 Meta ULC. All rights reserved