Non-Hodgkin's lymphoma subtypes over time in an unselected population of 646 patients: a study of clinico-pathological data and incidence based on a review using the REAL-classification

Leukemia & Lymphoma
H BrinckerP Johansen

Abstract

Biopsies from 646 consecutive unselected cases of non-Hodgkin's lymphoma from a Danish population-based registry were reclassified according to the REAL classification 1) to study the distribution of subtypes over time, and 2) to correlate a number of clinical parameters with the various subtypes. Two cohorts from 1986 and 1992, of 292 and 354 cases, respectively, were studied. From 1986 to 1992 diffuse large B-cell lymphoma showed a change in incidence of + 43.1%, as opposed + 2.5% for all other subtypes combined (p = 0.05), suggesting that the increasing general incidence of non-Hodgkin's lymphoma is due primarily to an increasing incidence of diffuse large B-cell lymphoma. A higher rate of cell proliferation was associated with an increasing chance of having extranodal disease. For the various subgroups there was good agreement between survival and the International prognostic index.

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Citations

Jun 24, 2008·Leukemia & Lymphoma·Giuseppe VisaniAlessandro Isidori
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ann-Sofi DubergKarl Ekdahl
Sep 20, 2005·European Journal of Epidemiology·Marie NordströmAnders Ekbom
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Dec 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ugo LuccaAngela Recchia
Nov 13, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Johannes WancataM Krautgartner
Sep 1, 2007·Human Molecular Genetics·Akinori MiyashitaUNKNOWN Japanese Genetic Study Consortium for Alzeheimer's Disease
Jan 13, 2015·European Journal of Heart Failure·Pavla CermakovaDorota Religa

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