Non-hypervascular hypointense nodules on Gd-EOB-DTPA-enhanced MRI as a predictor of outcomes for early-stage HCC

Hepatology International
Hidenori ToyodaYuji Kaneoka

Abstract

In patients with hepatocellular carcinoma (HCC), gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) often identifies non-hypervascular hypointense hepatic nodules during the hepatobiliary phase, but their prognostic significance is unclear. We conducted a prospective observational study to investigate the impact of non-hypervascular hypointense hepatic nodules detected by Gd-EOB-DTPA-enhanced MRI on the outcome of patients with early-stage HCC. Post-treatment recurrence and survival rates were analyzed in 138 patients with non-recurrent, early-stage HCC [Barcelona Clinic Liver Cancer (BCLC) stage 0 or A] and Child-Pugh A liver function according to the presence of non-hypervascular hypointense nodules on pretreatment Gd-EOB-DTPA-enhanced MRI. Non-hypervascular hypointense hepatic nodules were detected in 51 (37.0%) patients with early-stage HCC on pretreatment Gd-EOB-DTPA-enhanced MRI. Recurrence rates were significantly higher in patients with non-hypervascular hypointense nodules (p < 0.0001). Based on a multivariate analysis, the presence of non-hypervascular hypointense hepatic nodules on Gd-EOB-DTPA-enhanced MRI was independently associated with an increased ...Continue Reading

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Citations

Mar 20, 2015·Hepatology International·Sanjay Saini, Daniel S Pratt
May 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Society of Abdominal Radiology
Oct 30, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazuki MaesakaTetsuo Takehara
Aug 24, 2020·World Journal of Surgical Oncology·Xue-Qin LiHong-Jun Li
May 4, 2017·Infectious Agents and Cancer·Vincenza GranataAntonella Petrillo
Sep 19, 2020·European Journal of Radiology Open·Muntaser S AhmadHjouj Mohammad
Jul 11, 2021·Magnetic Resonance Imaging Clinics of North America·Silvia D ChangVictoria Chernyak

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