Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update.

Nutrients
Roxane LabrosseJean-Christoph Caubet

Abstract

Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summariz...Continue Reading

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Citations

Oct 23, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Simona BarniFrancesca Mori
Feb 15, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Natalie V HoffmannJohn E Fortunato
Jan 5, 2021·Current Opinion in Allergy and Clinical Immunology·Simona BarniFrancesca Mori
Jun 3, 2021·Nutrients·Domenico GarganoPaola Iovino
Jul 3, 2021·Nutrients·Teresa Di ChioOsvaldo Borrelli
Jul 3, 2021·Nutrients·Claudio Romano, Valeria Dipasquale
Jul 28, 2021·Primary Care·Arezoo RajaeeKatherine M Pohlgeers
Jul 1, 2021·Allergy and Asthma Proceedings·Melike OcakBulent Enis Sekerel

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