Abstract
Procalcitonin (PCT) is considered a sensitive and specific diagnostic and prognostic marker of systemic bacterial infection, but its value is questionable in certain clinical conditions, particularly in hemato-oncological patients. We analyzed PCT and C-reactive protein (CRP) levels in 56 patients of a pediatric hematology-oncology unit during 110 consecutive non-infectious febrile episodes related to administration of T-cell antibodies (group A; n = 22), alemtuzumab (monoclonal CD52 antibody, CAMPATH-1H/group B; n = 8), interleukin-2 (IL-2/group C; n = 41), prophylactic donor granulocyte transfusions (group D; n = 9), or to acute graft-versus-host disease (aGvHD/group E; n = 10) and compared the results with 20 episodes of Gram-negative sepsis (group F). In the majority of the non-infectious episodes PCT and CRP increased to serum levels statistically indistinguishable from Gram-negative sepsis. Median peak levels of PCT (normal < 0.5 ng/ml)/CRP (normal < 8 mg/l) for groups A-F were 4.34/59.0 (A), 10.14/93.5 (B), 1.11/175.0 (C), 1.43/164 (D), 0.96/34.0 (E), and 8.14 ng/ml /126.0 mg/l (F). Highest single levels were observed in groups A and F. PCT and CRP are of limited value as diagnostic markers of sepsis during T-cell-direct...Continue Reading
References
Apr 1, 1994·The Journal of Pediatrics·W R Hayden
Dec 15, 1996·The Journal of Clinical Investigation·M G WingA Compston
Dec 30, 1998·Leukemia & Lymphoma·E LegouffeT Commes
Aug 5, 2000·The Pediatric Infectious Disease Journal·P ToikkaO Ruuskanen
Sep 29, 2000·Critical Care Medicine·A AouifiJ J Lehot
Nov 4, 2000·Clinical and Diagnostic Laboratory Immunology·N M BlijlevensB E De Pauw
Feb 13, 2001·British Journal of Haematology·G FleischhackU Bode
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·B MüllerJ F Habener
Aug 11, 2001·Intensive Care Medicine·R SabatP Reinke
Sep 11, 2002·Burns : Journal of the International Society for Burn Injuries·Marius G DehneGunter Hempelmann
Oct 17, 2003·Bone Marrow Transplantation·H J DornbuschC Urban
Jan 15, 2004·The Journal of Infection·Yasunori OkadaAkihiro Morikawa
Feb 28, 2004·Lancet·Mirjam Christ-CrainBeat Müller
May 26, 2004·Cancer·Antonio JimenoLuis Paz-Ares
Jun 3, 2004·Diabetes, Obesity & Metabolism·Y SaijoR Kishi
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Sep 29, 2004·The Lancet Infectious Diseases·A M C van RossumA M Oudesluys-Murphy
Jan 20, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·H J DornbuschC Urban
Jan 25, 2005·Cancer·Nikolaos V SipsasDimitrios P Kontoyiannis
Mar 15, 2005·Chest·Hon-Kan YipChiung-Jen Wu
Mar 22, 2005·European Journal of Haematology·Lennart PerssonUlf Tidefelt
Apr 26, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W SchwingerC Urban
Jun 14, 2005·Annals of Hematology·Sabine MoussetHans Martin
Jan 13, 2006·European Journal of Haematology·Markus PihuschErnst Holler
Citations
Mar 18, 2009·Critical Care : the Official Journal of the Critical Care Forum·Helena BrodskaMarketa Markova
Oct 4, 2011·Internal Medicine·Yasuo MoriTakanori Teshima
Jan 21, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Jana UhrovaTomas Zima
Dec 7, 2010·International Journal of Antimicrobial Agents·Konrad Reinhart, Christiane S Hartog
May 9, 2012·Critical Care Medicine·Richard G WunderinkKurt D Reed
Mar 13, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shailendra Kapoor
Feb 8, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Y-X LyuM-Y Zhu
Jan 8, 2014·Critical Care : the Official Journal of the Critical Care Forum·Weijia WangDongmei Wen
May 24, 2016·Neurology. Neuroimmunology and Neuroinflammation·Katja ThomasTjalf Ziemssen
Feb 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ricardo Garcia Branco, Pedro Celiny Ramos Garcia
Dec 27, 2017·JAAPA : Official Journal of the American Academy of Physician Assistants·Elyse J Watkins, James Guerrini
Feb 8, 2018·Annals of Hematology·Volker StrengerChristian Urban
Dec 21, 2017·Terapevticheskiĭ arkhiv·N L Ryabkova, N N Vezikova
Apr 28, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Susan E SmithJulie Kalabalik-Hoganson
May 16, 2017·Journal of Medical Microbiology·Swapna R NathK Rajamohanan
Apr 30, 2009·Anaesthesia and Intensive Care·K M Ho, J Lipman
Jul 2, 2021·Frontiers in Oncology·Valerio NardonePierpaolo Correale
Jun 16, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sunyoung AhnSang-Guk Lee