PMID: 9166029Apr 1, 1997Paper

Non-infective colitis in infancy: evidence in favour of minor immunodeficiency in its pathogenesis

Archives of Disease in Childhood
A OjuawoP J Milla

Abstract

Forty two infants below the age of 2 years presenting with chronic non-infective diarrhoea and shown to have histologically proved colitis were investigated over a five year period. Allergic colitis was the most common cause of colitis, accounting for 62% of the cases. Other colitides diagnosed included: non-specific colitis, autoimmune enterocolitis, and ulcerative colitis accounting for 10% each; severe combined immunodeficiency 7%, and Crohn's disease 3%. A positive family history and a personal history of atopy were obtained in 48% and 29% of the cases respectively. Serum immunoglobulin A, IgG2, and IgG4 were very low in over 50% of the entire cohort of infants with colitis; 66% of those with severe combined immunodeficiency, autoimmune enterocolitis, and ulcerative colitis (n = 11) had low CD3 and CD4 T lymphocytes with an accompanying increase in CD8 in two thirds of those with severe combined immunodeficiency. T lymphocytes were normal in those with allergic colitis. Thus infants with proved non-infective colitis as a group show a high prevalence of IgA, IgG2, and IgG4 deficiency. It is likely that this minor deficiency of mucosa associated immunoglobulin production has a role in the pathogenesis of the colitic process.

References

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Citations

Sep 26, 2008·Inflammatory Bowel Diseases·Michael D Kappelman, Richard J Grand
Sep 18, 2010·Inflammatory Bowel Diseases·Daniel J B MarksStuart L Bloom
Jan 5, 2008·Diseases of the Colon and Rectum·Keiichi UchidaMasato Kusunoki
Mar 20, 2002·Current Allergy Reports·A M Lake
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Nikhil ThaparPeter J Milla
Jul 11, 2013·World Journal of Gastroenterology : WJG·Kriszta MolnárGábor Veres
Dec 3, 2010·Journal of Crohn's & Colitis·Nuray UsluAysel Yüce
Jun 12, 2008·European Journal of Pediatrics·Z CanniotoA Ventura
Aug 17, 2006·Pediatric Transplantation·Rupert Hinds, Anil Dhawan
Nov 5, 1999·Journal of Pediatric Surgery·I E WillettsM D Stringer
Jul 25, 2014·Gastroenterology·Holm H UhligUNKNOWN COLORS in IBD Study Group and NEOPICS
Jun 9, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J LemaleP Tounian
Sep 8, 2010·Journal of Pediatric Gastroenterology and Nutrition·Aron CsehGabor Veres
Jul 11, 2013·European Journal of Gastroenterology & Hepatology·Jung Ok ShimJeong Kee Seo

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