PMID: 16613563Apr 15, 2006Paper

Non-injection routes for allergen immunotherapy: focus on sublingual immunotherapy

Inflammation & Allergy Drug Targets
Giovanni PassalacquaGiorgio Walter Canonica

Abstract

Allergen specific immunotherapy, together with drugs and allergen avoidance, is a cornerstone in the management of respiratory allergy. The non-injection or local routes were developed with the main goal of improving the safety and minimizing the risk of those side effects, which can accompany the injection route. The pure oral route and the bronchial route showed, in the clinical trials, only a marginal efficacy with not negligible side effects. Therefore, these routes are no longer recommended for clinical use. The nasal route proved effective and safe, but its efficacy is strictly limited to the nose. Moreover, the practical problems with administration have made the use of nasal immunotherapy progressively declining. The efficacy of the sublingual route is confirmed by numerous controlled trials, and a meta analysis (in allergic rhinitis). The safety profile, as derived from clinical trials and post marketing surveillance studies, is satisfactory, with mild gastrointestinal complaints being the more frequent side effect reported. Recent studies have also demonstrated that SLIT has a long-lasting effect and a preventive effect on the onset of new skin sensitizations, and interesting data on adherence and mechanisms of action...Continue Reading

Citations

Oct 23, 2008·Current Allergy and Asthma Reports·Noel Rodríguez-PérezJay M Portnoy
Nov 19, 2009·Wiener klinische Wochenschrift·Zsolt SzépfalusiUNKNOWN Osterreichische Gesellschaft für Kinder und Jugendheilkunde
Sep 2, 2009·American Journal of Otolaryngology·Sarah K WiseRodney J Schlosser
Jan 29, 2008·Trends in Biotechnology·Prem L Bhalla, Mohan B Singh
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BachertP B Poulsen
Sep 29, 2009·Clinical and Experimental Otorhinolaryngology·Hyun ChangChae-Seo Rhee
Mar 28, 2009·Current Opinion in Allergy and Clinical Immunology·Desiree Larenas-Linnemann
Sep 23, 2011·Ear, Nose, & Throat Journal·Jamie WoodyRodney J Schlosser

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