Non-interferometric photoacoustic remote sensing microscopy

Light, Science & Applications
Parsin HajirezaRoger J Zemp

Abstract

Elasto-optical refractive index modulation due to photoacoustic initial pressure transients produced significant reflection of a probe beam when the absorbing interface had an appreciable refractive index difference. This effect was harnessed in a new form of non-contact optical resolution photoacoustic microscopy called photoacoustic remote sensing microscopy. A non-interferometric system architecture with a low-coherence probe beam precludes detection of surface oscillations and other phase-modulation phenomenon. The probe beam was confocal with a scanned excitation beam to ensure detection of initial pressure-induced intensity reflections at the subsurface origin where pressures are largest. Phantom studies confirmed signal dependence on optical absorption, index contrast and excitation fluence. In vivo imaging of superficial microvasculature and melanoma tumors was demonstrated with ~2.7±0.5 μm lateral resolution.

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Citations

Oct 17, 2017·Journal of Biomedical Optics·Christian BujRalf Brinkmann
Oct 28, 2019·Sensors·Xiangwei LinLidai Wang
Sep 19, 2019·Scientific Reports·Saad AbbasiParsin Haji Reza
Sep 18, 2020·Nature·Rami ShnaidermanVasilis Ntziachristos
Jun 2, 2017·Light, Science & Applications·Junjie Yao
Dec 5, 2019·Biomedical Optics Express·Saad AbbasiParsin Haji Reza
Jan 4, 2019·Biomedical Engineering Letters·Paul Kumar Upputuri, Manojit Pramanik
Mar 7, 2019·Light, Science & Applications·Georg WissmeyerVasilis Ntziachristos
Jul 16, 2019·Optics Letters·Nathaniel J M HavenRoger J Zemp
Feb 23, 2020·Sensors·Saad AbbasiParsin Haji Reza
Jul 28, 2020·Micromachines·Rayyan ManwarKamran Avanaki
Jan 10, 2018·Journal of Biophotonics·Deepu GeorgeParag V Chitnis
Aug 18, 2018·Applied Optics·Thanadet ChuangsuwanichManojit Pramanik
Sep 7, 2018·Optics Express·Kevan L BellRoger J Zemp
Jul 16, 2019·Optics Letters·Kevan L BellRoger J Zemp
Jun 6, 2020·Scientific Reports·Nadav ShabairouZeev Zalevsky
Oct 4, 2020·Sensors·Thomas ChalklenSohini Kar-Narayan
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Sep 15, 2020·Light, Science & Applications·Zhenyue ChenDaniel Razansky
Nov 10, 2018·Journal of Biomedical Optics·Pratik SamantLiangzhong Xiang
Jan 16, 2021·Optics Letters·Weizhi QiLei Xi
Oct 16, 2020·Scientific Reports·Benjamin R EcclestoneParsin Haji Reza
Dec 29, 2020·Physics in Medicine and Biology·Dhiman DasManojit Pramanik
Mar 5, 2021·Biomedical Optics Express·Benjamin R EcclestoneParsin Haji Reza
Nov 7, 2020·Scientific Reports·Kevan BellParsin Haji Reza
Mar 26, 2021·Photoacoustics·Jiasheng ZhouJiajia Luo

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Methods Mentioned

BETA
imaging techniques
xenograft

Software Mentioned

PAM
OR
MATLAB

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