Non-invasive (and minimally invasive) diagnosis of oesophageal varices

Journal of Hepatology
R de Franchis

Abstract

Current guidelines recommend screening all cirrhotic patients by endoscopy, to identify patients at risk of bleeding who should undergo prophylactic treatment. However, since the prevalence of varices in cirrhotic patients is variable, universal screening would imply a large number of unnecessary endoscopies and a heavy burden for endoscopy units. In addition, compliance to screening programs may be hampered by the perceived unpleasantness of endoscopy. Predicting the presence of oesophageal varices by non-invasive means might increase compliance and would permit to restrict the performance of endoscopy to those patients with a high probability of having varices. Over the years, several studies have addressed this issue by assessing the potential of biochemical, clinical and ultrasound parameters, transient elastography, CT scanning and video capsule endoscopy. The platelet count/spleen diameter ratio, CT scanning and video capsule endoscopy have shown promising performance characteristics, although none of them is equivalent to EGD. These methods are perceived by patients as preferable to endoscopy and thus might increase adherence to screening programs. Whether this will compensate for the lower sensitivity of these alternati...Continue Reading

References

Mar 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BendtsenP Matzen
Sep 1, 1996·Journal of Hepatology·R de Franchis
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D GraceJ Rodes
Sep 11, 1999·Journal of Gastroenterology and Hepatology·F H NgC S Cheng
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F SchepisG Raimondo
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T F Imperiale, N Chalasani
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oliviero RiggioCarlo Merkel
Feb 15, 2003·Journal of Hepatology·Roberto de Franchis
Jul 23, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K C ThomopoulosV N Nikolopoulou
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Claudia O ZeinPaul Angulo
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicolas CarbonellRaoul Poupon
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco VizzuttiMassimo Pinzani
Jun 20, 2007·Journal of Clinical Gastroenterology·James R BurtonAtif Zaman
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Dec 18, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L R PenaA Bosch
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roman E PerriPatrick S Kamath
Apr 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roberto de FranchisRami Eliakim

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Citations

Aug 6, 2009·Nature Reviews. Gastroenterology & Hepatology·Roberto de Franchis
Apr 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Julia O'BrienAndrew K Burroughs
Feb 22, 2011·Journal of Pediatric Gastroenterology and Nutrition·Simon C LingBenjamin L Shneider
Jul 20, 2012·International Journal of Hepatology·Amar Nath MukerjiAshokkumar Jain
Jul 19, 2013·World Journal of Gastroenterology : WJG·De-Run KongJian-Ming Xu
May 4, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Prabhakar Holikatti, Sandeep Grover
Mar 8, 2011·Digestive Diseases and Sciences·Michael J LippAlbert D Min
Feb 1, 2013·Expert Review of Gastroenterology & Hepatology·Annalisa BerzigottiJaime Bosch
Feb 3, 2016·Abdominal Radiology·Shingo KihiraBachir Taouli
Oct 2, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yuan Heng MoSteven Shinn-Forng Peng
Nov 12, 2013·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Basma Abdel Moneim Dessouky, El Sayed Mohamed Abdel Aal
May 21, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Antonio ColecchiaDavide Festi
Aug 5, 2010·Clinics in Liver Disease·Emanuele RondonottiRoberto de Franchis
Apr 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutDidier Lebrec
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutDidier Lebrec
Jan 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Beom Kyung KimKwang Hyub Han
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Beom Kyung KimDo Young Kim
Jul 20, 2011·Journal of Hepatology·Laurent CasteraJaime Bosch
Sep 17, 2010·Journal of Clinical Gastroenterology·Eric B Cohen, Nezam H Afdhal
Nov 12, 2009·Journal of Clinical Gastroenterology·Kangshun ZhuHong Shan
May 24, 2017·Gastroenterology Report·Bogdan Procopet, Annalisa Berzigotti
Nov 28, 2017·Journal of Pediatric Gastroenterology and Nutrition·Marina Rossato AdamiSandra Maria Gonçalves Vieira
Jul 2, 2009·Journal of Clinical Gastroenterology·Matti Waterman, Ian M Gralnek
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Hong ZhaoLanjuan Li
Apr 29, 2021·European Journal of Gastroenterology & Hepatology·Mahmoud A ElkerdawyMohamed H Emara

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