Non-invasive and tracheostomy invasive ventilation in amyotrophic lateral sclerosis: Utilization and survival rates in a cohort study over 12 years in Germany.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Susanne SpittelThomas Meyer

Abstract

The aim of this study was to investigate utilization rates, treatment pathways and survival prognosis in patients with amyotrophic lateral sclerosis (ALS) undergoing non-invasive (NIV) and tracheostomy invasive ventilation (TIV) in a real-world setting. A prospective cohort study using a single-centre register of 2702 ALS patients (2007 to 2019) was conducted. Utilization of NIV/TIV and survival data were analysed in three cohorts: (i) non-NIV; (ii) NIV (NIV without subsequent TIV); and (iii) TIV (including TIV preceded by NIV). A total of 1720 patients with available data were identified, 72.0% of whom (n = 1238) did not receive ventilation therapy. NIV was performed in 20.8% of patients (n = 358). TIV was performed in 9.5% of patients (n = 164), encompassing both primary TIV (7.2%, n = 124) and TIV with preceding NIV (2.3%, n = 40). TIV was more often utilized without previous NIV (25.7% vs. 8.3% of all ventilated patients), demonstrating that primary TIV was the prevailing pathway for invasive ventilation. The median (range) survival was significantly longer in the NIV cohort (40.8 [37.2-44.3] months) and the TIV cohort (82.1 [68.7-95.6] months) as compared to the non-NIV cohort (33.6 [31.6-35.7] months). Although NIV repres...Continue Reading

References

Jan 1, 1996·The American Journal of Clinical Nutrition·E J KasarskisC J McClain
Sep 25, 1998·Journal of Neurology·G D BorasioN Yanagisawa
Sep 25, 1999·Neurology·J C DesportP Couratier
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Jun 7, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·S ZoccolellaUNKNOWN SLAP Registry
Jul 27, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Peter Munch AndersenUNKNOWN EALSC Working Group
Oct 19, 2007·PLoS Medicine·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Apr 16, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·R ChadwickIan E Smith
Jul 28, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·A ChiòUNKNOWN PARALS
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Oct 21, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Adriano ChiòUNKNOWN PARALS
Jan 31, 2012·Journal of Palliative Medicine·Pia Sander DreyerCharlotte Kirkegård Lorenzen
May 19, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L LeonardisG Vidmar
Sep 20, 2012·Journal of the Neurological Sciences·Rossella SpataroVincenzo La Bella
Oct 9, 2012·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Judith RabkinHiroshi Mitsumoto
Feb 5, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Eleni GeorgoulopoulouJessica Mandrioli
Sep 27, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Pia DreyerMichael Felding
Jan 23, 2014·Muscle & Nerve·Nicola FiniJessica Mandrioli
Jul 16, 2014·Journal of the Neurological Sciences·Muneyoshi TagamiToshiaki Hanafusa
Apr 11, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·David J BerlowitzPaul Talman
Aug 19, 2016·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Dagmar KettemannThomas Meyer
Feb 22, 2017·Journal of Neurology·Angela RosenbohmUNKNOWN ALS Registry Study Group
Dec 22, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M VitaccaUNKNOWN ALS RESPILOM Study Group
Feb 1, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Andreas FunkeThomas Meyer
Nov 15, 2018·JMIR Rehabilitation and Assistive Technologies·Robert MeyerAndré Maier
Jun 12, 2019·Neurology·Nimish J ThakoreLoutfi S Aboussouan
Jul 6, 2019·Practical Neurology·Martin R TurnerKevin Talbot
Aug 9, 2019·Neurology·Magdalena Kuzma-KozakiewiczDorothée Lulé
Jan 16, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Naoki HayashiGen Sobue
Apr 23, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Thomas MeyerSusanne Spittel

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Apr 4, 2021·Brain Sciences·Tara PeseschkianOlivia Schreiber-Katz

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