Non-invasive assessment of arterial stiffness in patients with rheumatoid arthritis: a systematic review and meta-analysis of literature studies

Annals of Medicine
Pasquale AmbrosinoMatteo Nicola Dario Di Minno

Abstract

Patients with rheumatoid arthritis (RA) have an increased cardiovascular (CV) morbidity and mortality. Pulse-wave velocity (PWV) and augmentation index (AIx) are non-invasive methods to assess arterial stiffness, a marker of CV risk. We performed a meta-analysis evaluating the impact of RA on aortic-PWV, brachial-PWV, brachial-ankle (ba-) PWV, AIx, and AIx normalized to a 75 beats/minute heart rate (AIx@75). Studies evaluating the relationship between RA and aortic-PWV, brachial-PWV, ba-PWV, AIx, and AIx@75 were systematically searched. A total of 25 studies (1,472 RA patients, 1,583 controls) were included. Compared to controls, RA patients showed a significantly higher aortic-PWV (mean difference 1.32 m/s; 95% CI 0.77, 1.88; P < 0.00001), ba-PWV (MD 198.42 cm/s; 95% CI 45.79, 342.76; P = 0.01), AIx (MD 11.50%; 95% CI 5.15, 17.86; P = 0.0004), and AIx@75 (MD 6.99%; 95% CI 4.92, 9.06; P < 0.00001), with a trend toward a higher brachial-PWV (MD 0.34 m/s; 95% CI -0.03, 0.70; P = 0.07). When analyzing studies on early RA, the difference in aortic-PWV among RA patients and controls was even higher (MD 2.30 m/s; 95% CI 1.15, 3.45; P < 0.0001). Meta-regression showed that a more severe inflammatory status impacted on aortic-PWV, AIx,...Continue Reading

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Citations

Feb 2, 2016·International Journal of Cardiology·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
Feb 8, 2016·The International Journal of Cardiovascular Imaging·Galia KarpMahmoud Abu-Shakra
Nov 9, 2015·European Journal of Internal Medicine·Matteo Nicola Dario Di MinnoElena Tremoli
Jan 1, 2016·The Journal of Clinical Hypertension·Maria PikilidouPantelis Zebekakis
Jun 10, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·E BartoloniRoberto Gerli
Mar 22, 2018·Scandinavian Cardiovascular Journal : SCJ·Panagiota AnyfantiStella Douma
Feb 4, 2016·Journal of Korean Medical Science·Diana S NovikovaEvgeny L Nasonov
Jan 14, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alessandro MalobertiGuido Grassi
May 6, 2019·International Journal of Molecular Sciences·Valentina MercurioFrancesca W Rossi
May 2, 2019·Journal of the American Society of Nephrology : JASN·Luca ZanoliPierre Boutouyrie
Feb 16, 2019·British Journal of Pharmacology·Jennifer J DuPontIris Z Jaffe
Oct 11, 2019·Biomarkers in Medicine·Luca Zanoli
May 24, 2019·Journal of Cardiovascular Translational Research·Lebogang MokotediAletta M E Millen
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Jun 24, 2017·Scandinavian Cardiovascular Journal : SCJ·Abdullah Nabi AslanTahir Durmaz
Jun 9, 2017·Internal and Emergency Medicine·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
Jun 30, 2018·International Journal of Molecular Sciences·Aikaterini AridaPetros P Sfikakis
Jul 17, 2020·Current Hypertension Reports·P AnyfantiE Gkaliagkousi
Aug 25, 2017·Nature Reviews. Cardiology·Elena BartoloniRoberto Gerli
Mar 3, 2018·Frontiers in Medicine·Fabiola AtzeniMaurizio Turiel
Dec 31, 2018·Pediatric Rheumatology Online Journal·Hanne Aaserud AulieSvend Aakhus
May 6, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alessandro MalobertiCristina Giannattasio
Apr 10, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maria Del Mar VilaMaria Grau
Jun 17, 2021·Scandinavian Journal of Rheumatology·F K FöhseA G Semb

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