Non-invasive assessment of hepatic fibrosis: comparison of MR elastography to transient elastography and intravoxel incoherent motion diffusion-weighted MRI

Abdominal Radiology
Fangfang FuMeiyun Wang

Abstract

To compare the ability of MR elastography (MRE) with transient elastography (TE) and intravoxel incoherent motion (IVIM) diffusion-weighted MRI in staging hepatic fibrosis (HF). 100 patients with chronic liver disease and 25 healthy volunteers underwent preoperative MRE, IVIM on a 3T MRI unit, and ultrasound-based TE. Liver stiffness measurement from MRE (LSM-MRE) and liver stiffness measurement from TE (LSM-TE) were measured; four diffusion parameters including the true diffusion coefficient (Dt), pseudo-diffusion coefficient, perfusion fraction (f), and apparent diffusion coefficient (ADC) were calculated. Receiver operating characteristic (ROC) curves were performed for significant parameters to compare the diagnosis performance for detecting HF. LSM-MRE and LSM-TE values showed positive correlation with the fibrosis stage (r = 0.910 and 0.813, P < 0.001). Dt, f, and ADC values showed negative correlation with the fibrosis stage (r = - 0.727, - 0.503, and - 0.601, all P < 0.001). The area under the ROC curve (AUC) of LSM-MRE (AUC = 0.965, 0.957, 0.983) was significantly higher than that of LSM-TE (AUC = 0.906, 0.913, 0.931) and Dt (AUC = 0.875, 0.879, 0.861) in discriminating significant HF (≥ F2), advanced HF (≥ F3), or cir...Continue Reading

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Citations

Jun 4, 2020·Journal of Magnetic Resonance Imaging : JMRI·Shuyi YangFei Shan
Apr 26, 2020·The American Journal of Tropical Medicine and Hygiene·Marcus J SchultzArjen M Dondorp
Jul 25, 2020·Abdominal Radiology·Ilkay S IdilmanSudhakar K Venkatesh
Jul 21, 2020·World Journal of Gastroenterology : WJG·Zheng YeBin Song
Apr 6, 2021·Journal of Magnetic Resonance Imaging : JMRI·Chang LiuFei Yang

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