Non-invasive assessment of liver fibrosis and prognosis: an update on serum and elastography markers

Expert Review of Gastroenterology & Hepatology
Uchenna Agbim, Sumeet K Asrani

Abstract

Non-invasive assessment of fibrosis is increasingly utilized in clinical practice to diagnose hepatic fibrosis. Non-invasive assessment of liver fibrosis relies on biologic and/or physical properties to assess tissue fibrosis. Serum markers estimate fibrosis by incorporating markers reflecting hepatic function (indirect markers) and/or markers measuring extracellular matrix degradation/fibrogenesis (direct markers). Radiology based techniques relay the mechanical properties and stiffness of a tissue, with increased stiffness associated with more advanced fibrosis. Areas covered: In this comprehensive review, the recent literature discussing serum markers and elastography-based techniques will be covered. These modalities are also explored in the setting of various liver diseases. Expert opinion: The etiology of liver disease and clinical context should be taken into consideration when non-invasive markers are incorporated in clinical practice. Non-invasive assessment of fibrosis has been most extensively utilized in hepatitis C, followed by hepatitis B and nonalcoholic fatty liver disease, but its role remains less developed in other etiologies of liver disease such as alcohol-associated liver disease and autoimmune liver disea...Continue Reading

References

Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Dec 4, 2004·Gastroenterology·William M C RosenbergUNKNOWN European Liver Fibrosis Group
Jun 30, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F LokChihiro Morishima
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul CalèsFrançoise Lunel
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Apr 9, 2008·Gastroenterology·Mireen Friedrich-RustEva Herrmann
Nov 4, 2008·Journal of Hepatology·Paul CalèsFrançoise Lunel
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhong-Hua LinShi-Ying Xuan
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe CorpechotRaoul Poupon
Feb 22, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thierry PoynardFrederic Charlotte
Nov 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donghee KimTerry M Therneau
Mar 26, 2013·Journal of Hepatology·Ralf LichtinghagenMatthias J Bahr
Feb 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julien VergniolPaul Calès
Mar 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Jing-Houng WangShue-Shian Chiou
Jul 9, 2014·Journal of Pediatric Gastroenterology and Nutrition·Seung KimHong Koh
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
Oct 12, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRichard L Ehman
Dec 17, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beomseok SuhBeLong Cho
Dec 22, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nezam H AfdhalJohn G McHutchison
Apr 11, 2015·European Journal of Gastroenterology & Hepatology·Cumali EfeStaffan Wahlin
Apr 24, 2015·AJR. American Journal of Roentgenology·An TangClaude B Sirlin
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado
Jul 15, 2015·Digestive Diseases·Laurent Castera
Jul 21, 2015·Clinical Biochemistry·Manuela G NeumanRadu Nanau
Jul 22, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mamatha BhatGiada Sebastiani
Sep 18, 2015·Expert Review of Gastroenterology & Hepatology·Michael HaganJayant Talwalkar

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Citations

Jul 30, 2019·Expert Review of Gastroenterology & Hepatology·Marco ArreseJuan Pablo Arab
Jun 9, 2020·Expert Review of Gastroenterology & Hepatology·Xian XingLi Yang
Aug 25, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Roberto CatanzaroFrancesco Marotta
Sep 25, 2019·Current HIV Research·Theodoros AndroutsakosGregorios Hatzis
Sep 16, 2020·Wiener klinische Wochenschrift·Yusuf Coskun, Ilhami Yuksel
Oct 8, 2020·Cells·Yinzong XiaoJessica Howell
Nov 17, 2020·Zeitschrift für Gastroenterologie·C SarrazinUNKNOWN Collaborators:
Feb 6, 2021·Canadian Journal of Gastroenterology & Hepatology·Changzhou CaiFeng Ji
Oct 23, 2020·Digestive Diseases and Sciences·Yejoo Jeon, Berkeley N Limketkai
Feb 3, 2021·Gastroenterology·Don C Rockey, Scott L Friedman
Apr 5, 2021·Lancet·Christopher E M GriffithsJonathan N W N Barker
Sep 28, 2020·Seminars in Ultrasound, CT, and MR·Donald O IbeDavid M Biko
Jun 14, 2021·Pediatric Transplantation·Amy G FeldmanUNKNOWN SPLIT Education Committee, the Pediatric Transplant Hepatology Fellowship Program Directors
Jul 17, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ignazio GrattaglianoClaudio Cricelli
Aug 14, 2021·Revista de gastroenterología de México·F Higuera-de-la-TijeraE Wolpert-Barraza

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