Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness

World Journal of Gastroenterology : WJG
C Stasi, Stefano Milani

Abstract

The assessment of the fibrotic evolution of chronic hepatitis has always been a challenge for the clinical hepatologist. Over the past decade, various non-invasive methods have been proposed to detect the presence of fibrosis, including the elastometric measure of stiffness, panels of clinical and biochemical parameters, and combinations of both methods. The aim of this review is to analyse the most recent data on non-invasive techniques for the evaluation of hepatic fibrosis with particular attention to cost-effectiveness. We searched for relevant studies published in English using the PubMed database from 2009 to the present. A large number of studies have suggested that elastography and serum markers are useful techniques for diagnosing severe fibrosis and cirrhosis and for excluding significant fibrosis in hepatitis C virus patients. In addition, hepatic stiffness may also help to prognosticate treatment response to antiviral therapy. It has also been shown that magnetic resonance elastography has a high accuracy for staging and differentiating liver fibrosis. Finally, studies have shown that non-invasive methods are becoming increasingly precise in either positively identifying or excluding liver fibrosis, thus reducing th...Continue Reading

References

Dec 1, 1979·European Journal of Clinical Investigation·H RohdeR Timpl
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F CadranelF Degos
Apr 9, 2002·Ultrasound in Medicine & Biology·Kathryn NightingaleGregg Trahey
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Mar 5, 2003·Journal of Viral Hepatitis·F ToccaceliUNKNOWN Italian Hepanet Group
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Feb 4, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne ZiolMichel Beaugrand
Jun 30, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F LokChihiro Morishima
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul CalèsFrançoise Lunel
Jul 11, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jose A CarriónXavier Forns
Aug 5, 2006·Alimentary Pharmacology & Therapeutics·E Gómez-DomínguezR Moreno-Otero
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masahiko KodaYoshikazu Murawaki
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Aug 30, 2007·Journal of Gastroenterology and Hepatology·Yusuf ErzinAykut Ferhat Celik
Dec 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert J FontanaUNKNOWN Halt-C Trial Group
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincenza CalvarusoAmar Paul Dhillon
Jun 2, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C StasiM Pinzani
Jul 25, 2009·The New England Journal of Medicine·John G McHutchisonUNKNOWN IDEAL Study Team
Mar 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Savino BrunoPatrick Maisonneuve
Mar 20, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuko ArimaKentaro Yoshioka
Sep 11, 2010·BMC Gastroenterology·Mireen Friedrich-RustChristoph Sarrazin
Oct 13, 2010·World Journal of Gastroenterology : WJG·Naohiro IchinoKentaro Yoshioka
Oct 26, 2010·Japanese Journal of Radiology·Utaroh MotosugiTsutomu Araki
Nov 17, 2010·European Journal of Gastroenterology & Hepatology·Ellen Sloth AndersenNina Weis
Mar 5, 2011·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jul 14, 2011·Journal of Magnetic Resonance Imaging : JMRI·Norah J ShireRichard L Ehman
Nov 23, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Robert J FontanaUNKNOWN HALT-C Trial Group
Aug 9, 2012·Biomarker Insights·Tianhui LiuFederica Genovese

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Citations

Nov 9, 2016·MMW Fortschritte der Medizin·Florian Simon, Christoph Antoni
Feb 10, 2018·Journal of Gastroenterology and Hepatology·Christopher Sung-Huan YehChau-Ting Yeh
May 31, 2018·Current Medical Research and Opinion·Cristina StasiFrancesco Cipriani
Aug 9, 2018·Clinical and Molecular Hepatology·Jeong-Ju YooUNKNOWN the Korean Association for the Study of the Liver (KASL)-Korea Nonalcoholic fatty liver Study Group (KNSG)
Sep 10, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoji IshizuMitsuhiro Fujishiro
Feb 25, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ki-Chul SungChristopher D Byrne
Nov 20, 2019·European Journal of Gastroenterology & Hepatology·El-Shahat A TosonHatem A El-Mezayen
Mar 14, 2018·World Journal of Gastroenterology : WJG·Li-Ting XieTian-An Jiang
Sep 7, 2018·Canadian Journal of Gastroenterology & Hepatology·Feiyue ZhangSujuan Fei
Jul 28, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Maud MenardPatrick Lecoindre
Jan 28, 2017·World Journal of Gastroenterology : WJG·Cristina Stasi, Stefano Milani
Dec 14, 2016·World Journal of Gastroenterology : WJG·Caterina SilvestriCristina Stasi
May 16, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zijie WangMin Gu
May 31, 2018·World Journal of Hepatology·Cristina StasiFrancesco Cipriani
Aug 14, 2019·Healthcare Informatics Research·Nahla H BarakatNadia Ahmed
Oct 1, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aparna Srinivasa BabuSudhakar K Venkatesh
Sep 1, 2017·Biomedical Optics Express·E Teran-HinojosaJ Hernández-Ruiz
Feb 6, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·G Eser Karlidag, O Arslan Solmaz

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