Non-invasive cancer detection using volatile biomarkers: Is urine superior to breath?

Medical Hypotheses
Roland Becker

Abstract

In recent years numerous reports have highlighted the options of chemical breath analysis with regard to non-invasive cancer detection. Certain volatile organic compounds (VOC) supposedly present in higher amounts or in characteristic patterns have been suggested as potential biomarkers. However, so far no clinical application based on a specific set of compounds appears to exist. Numerous reports on the capability of sniffer dogs and sensor arrays or electronic noses to distinguish breath of cancer patients and healthy controls supports the concept of genuine cancer-related volatile profiles. However, the actual compounds responsible for the scent are completely unknown and there is no correlation with the potential biomarkers suggested on basis of chemical trace analysis. It is outlined that specific features connected with the VOC analysis in breath - namely small concentrations of volatiles, interfering background concentrations, considerable sampling effort and sample instability, impracticability regarding routine application - stand in the way of substantial progress. The underlying chemical-analytical challenge can only be met considering the severe susceptibility of VOC determination to these adverse conditions. Theref...Continue Reading

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Citations

Dec 5, 2020·Medical Hypotheses·Ayman BannagaRamesh P Arasaradnam
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayman S BannagaRamesh P Arasaradnam

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