Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by (1)H-MRS and neuropathology

NMR in Biomedicine
T HammenH Stefan

Abstract

We assessed (1)H-MRS as a screening tool for detection of hippocampal sclerosis in patients with temporal lobe epilepsy (TLE). (1)H-MRS was carried out in the hippocampus of 23 patients with unilateral TLE. Metabolite alterations detected by (1)H-MRS correlated with degree of segmental neuronal cell loss and amount of astrogliosis. Positive correlation was found between total N-Acetylaspartate (tNAA) reduction and neuronal density in hippocampal CA1 (P < 0.001), CA3 (P = 0.015), and CA4 subfields (P = 0.031) and the dentate gyrus (P = 0.006). Neuronal cell loss in CA1 turned out to be the most predictive and only significant variable for tNAA reduction (P = 0.027). The association between myo-inositol (m-Ins) and astroglial glial fibrillary acidic protein (GFAP) expression revealed significantly increased m-Ins concentrations associated with diffuse astrogliosis (m-Ins = 6.4 +/- 1.1 institutional units) compared with gliosis restricted to isolated sectors of the hippocampus (i.e. hilus) (m-Ins = 5.2 +/- 1.2 institutional units) (P = 0.039). A negative correlation was found between m-Ins and neuronal loss in the CA4 subfield of the hippocampus (P = 0.028). Our results support (1)H-MRS as a suitable non-invasive method for preope...Continue Reading

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Citations

Oct 19, 2011·Biomarkers in Medicine·Annamaria Vezzani, Alon Friedman
Mar 20, 2014·Journal of Neural Transmission·Angelika MenneckeNorbert Thürauf
Oct 28, 2014·Expert Review of Neurotherapeutics·Alon FriedmanDaniela Kaufer
Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Aparna SinghalM Albert Thomas
Jul 4, 2015·Journal of Neurology·Juri-Alexander WittChristoph Helmstaedter
Apr 24, 2012·Neuropharmacology·Annamaria VezzaniRaymond J Dingledine
Sep 10, 2014·Neuroscience·H AmhaoulS Dedeurwaerdere
Aug 4, 2009·Journal of the Neurological Sciences·Mikhail F ChernovKintomo Takakura
Apr 24, 2017·Neurochemical Research·Annamaria VezzaniTeresa Ravizza
Jan 23, 2020·Current Medical Imaging Reviews·Ioannis TsougosKostas N Fountas

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