Non-invasive determination of effective stroke volume. Evaluation of a CO2-rebreathing method in normal subjects and patients

Clinical Physiology
J OhlssonB Wranne

Abstract

A CO2-rebreathing method for the determination of stroke volume (SV) was evaluated at rest by comparison with the direct Fick technique in 50 randomly selected patients with valvular heart disease. Patients with intracardiac shunts were excluded. Objective criteria for acceptance of a measurement were set to ensure reliable results. Forty-six of the 50 patients fulfilled these criteria. The rebreathing manoeuvre is, in itself, an effort for the patient, leading to a change in steady state which excludes simultaneous comparison with the direct Fick method. Day-to-day variation of the SV measured with the CO2-method was therefore assessed first, and found to be low. Because of this low day-to-day variation, a comparison of stroke volumes measured one day with the CO2-method and next day with the direct Fick technique was found to be acceptable. In the determination of SV in the supine position, there was no significant difference between the two methods (SVCO2 = 5.2 + 0.90 X SVFick, r = 0.90, SDres = 9.4 ml, n = 46), while cardiac output was significantly higher when measured with the CO2 technique than with the direct Fick method (22%, P less than 0.001). Ten of 12 patients with signs of obstructive lung disease managed to produ...Continue Reading

References

Aug 12, 1976·European Journal of Applied Physiology and Occupational Physiology·D H Paterson, D A Cunningham
Oct 1, 1976·Respiration Physiology·L E FarhiA K Ellis
Mar 1, 1968·Journal of Applied Physiology·G MuiesanE Petz

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Citations

Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·J Ohlsson, B Wranne
Mar 1, 1986·Journal of the American College of Cardiology·J Ohlsson, B Wranne
Sep 1, 1990·Clinical Physiology·B J Sjöberg, B Wranne
Feb 13, 2010·Journal of Evolutionary Biology·P Carazo, E Font
Jan 1, 1988·Acta Medica Scandinavica·J AhlnerJ Ohlsson

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