Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy

Journal of the European Academy of Dermatology and Venereology : JEADV
M UlrichS Astner

Abstract

Actinic cheilitis (AC) represents the equivalent of actinic keratosis on the lip. Various treatment modalities are available and the efficacy of diclofenac in hyaluronic acid has recently been described. Reflectance confocal microscopy (RCM) is a non-invasive imaging technique which has recently been applied for the diagnosis of actinic keratoses. Herein, we describe the applicability of RCM for the diagnosis of AC and for monitoring of treatment response of AC to diclofenac in hyaluronic acid. Ten Caucasian patients with clinical suspicion for AC were included in this study. To obtain a non-invasive diagnosis, RCM was performed at baseline, followed by biopsy and respective confocal-histopathological correlation. Six patients with a histological diagnosis of AC were treated with diclofenac in hyaluronic acid, whereby monitoring was performed by RCM. Reflectance confocal microscopy was able to correctly identify 6/7 cases of AC and 3/3 cases of benign lesions. The most important RCM criteria for diagnosis of AC were cellular atypia at the stratum spinosum and granulosum with atypical honeycomb pattern. One patient with AC was misclassified as inflammatory cheilitis by RCM as it showed marked inflammatory response and lacked cle...Continue Reading

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Citations

Apr 1, 2012·Dermatology Practical & Conceptual·Martina UlrichSalvador Gonzalez
May 10, 2013·Der Internist·D Krüger-CorcoranE Stockfleth
Oct 2, 2012·Dermatologic Clinics·Caterina LongoGiovanni Pellacani
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Mar 6, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·H LiuF Zhang
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Dec 4, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·J Malvehy
Mar 26, 2014·Computer Methods and Programs in Biomedicine·Panagiota SpyridonosIoannis D Bassukas
Oct 11, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Nigel G MaherPascale Guitera
Oct 27, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Y-F MaP Humbert
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Apr 13, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Virginia GarofaloLuca Bianchi

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