Non-invasive Diagnosis of Fibrosis in Non-alcoholic Fatty Liver Disease

Journal of Clinical and Experimental Hepatology
Anil Arora, Praveen Sharma

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed as well as in developing countries. Its prevalence continues to rise currently affecting approximately 20-30% of adults and 10% of children in the United States. Non-alcoholic fatty liver disease represents a wide spectrum of conditions ranging from fatty liver, which in general follows a benign non-progressive clinical course, to non-alcoholic steatohepatitis (NASH), a more serious form of NAFLD that may progress to cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and fibrosis; however, several non-invasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. There has been a substantial development of non-invasive risk scores, biomarker panels, and radiological modalities to identify at risk patients with NAFLD without recourse to liver biopsy on a routine basis. Examples include combination of serum markers like NAFLD fibrosis score (NFS), BARD score, fibrometer, FIB4, and non-invasive tools like fibroscan which assess fibrosis in patients with NAFLD. Other markers of fibr...Continue Reading

Citations

Feb 28, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Yolanda Sánchez-TorrijosManuel Romero-Gómez
Apr 21, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuichiro EguchiYoshio Sumida
Aug 6, 2020·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Mohsen SaffariAmir H Pakpour
Sep 27, 2019·International Journal of Environmental Research and Public Health·Viera KupčováLadislav Turecký
Jan 1, 2016·Clinical Medicine Insights. Therapeutics·Bubu A Banini, Arun J Sanyal
Apr 12, 2017·The American Journal of Gastroenterology·Bubu A Banini, Arun J Sanyal
Oct 16, 2015·Expert Review of Gastroenterology & Hepatology·Pegah GolabiZobair M Younossi
Feb 1, 2018·European Journal of Gastroenterology & Hepatology·Pamela ValvaMaría V Preciado
Mar 29, 2019·Oxidative Medicine and Cellular Longevity·Olivia Vázquez-MartínezMauricio Díaz-Muñoz
Jul 21, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Shih-Hsi SongChing-Feng Huang
Jun 25, 2021·World Journal of Gastroenterology : WJG·Tasur Kumar SeenRaghav Bansal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Carmen Fierbinteanu-BraticeviciCatalin Carstoiu
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Anna WieckowskaAriel E Feldstein
© 2022 Meta ULC. All rights reserved