Non-invasive diagnosis of pink basal cell carcinoma: how much can we rely on dermoscopy and reflectance confocal microscopy?

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Alexander WitkowskiGiovanni Pellacani

Abstract

Non-pigmented 'pink' cutaneous lesions in differential diagnosis with basal cell carcinoma may present a challenge for clinicians. Our objective was to determine the potential improvement of diagnostic accuracy using combined dermoscopy-reflectance confocal microscopy (RCM) image evaluation. Two hundred and sixty clinically equivocal 'pink' cutaneous lesions were evaluated retrospectively. Reader accuracy was tested with dermoscopy images only vs. RCM and combined dermoscopy-RCM images. Out of 260 equivocal 'pink' cutaneous lesions, there were 114 basal cell carcinomas within a total of 140 malignancies that included 12 melanomas, 13 squamous cell carcinomas, and 1 other malignancy type. Dermoscopy only evaluation resulted in an overall sensitivity of 85.1% and specificity of 92.4%, resulting in a positive predictive value (PPV) of 89.8%, with 1 of 12 melanomas misdiagnosed. RCM evaluation resulted in an overall sensitivity of 85.1% and specificity of 93.8%, resulting in a PPV of 91.5%, with no melanomas misdiagnosed. Combined dermoscopy-RCM evaluation resulted in an overall sensitivity of 77.2% and specificity of 96.6%, resulting in a PPV of 94.6%. The combination of dermoscopy-RCM evaluation significantly improves the accurac...Continue Reading

References

Jun 1, 1995·The Journal of Investigative Dermatology·M RajadhyakshaR R Anderson
Aug 5, 2000·Archives of Dermatology·S W MenziesB Katz
Jun 14, 2002·Journal of the American Academy of Dermatology·Paolo CarliBenvenuto Giannotti
Nov 27, 2002·Journal of the American Academy of Dermatology·Salvador González, Zeina Tannous
Dec 8, 2004·Journal of the American Academy of Dermatology·Sarita NoriSalvador González
Dec 13, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jason Giacomel, Iris Zalaudek
Mar 21, 2006·Journal of the American Academy of Dermatology·Anna Liza Chan AgeroAllan C Halpern
Jul 3, 2008·The British Journal of Dermatology·N R TelferUNKNOWN British Association of Dermatologists
Jul 12, 2008·The British Journal of Dermatology·C F HealD Weedon
Oct 16, 2009·Journal of the American Academy of Dermatology·Davide AltamuraKetty Peris
Feb 23, 2010·Lancet·Vishal MadanRolf-Markus Szeimies
Aug 17, 2010·Journal of the American Academy of Dermatology·Iris ZalaudekGiuseppe Argenziano
Aug 17, 2010·Journal of the American Academy of Dermatology·Iris ZalaudekGiuseppe Argenziano
Feb 26, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E Daudén, UNKNOWN BASALE Study Group
Jul 12, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·P MatteucciP Stanley
Nov 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tracey N LiebmanAshfaq A Marghoob
Jan 19, 2012·The British Journal of Dermatology·A LomasF Bath-Hextall
Apr 27, 2012·European Journal of Dermatology : EJD·Maria Concetta FargnoliKetty Peris
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
Feb 5, 2013·The British Journal of Dermatology·C LongoG Pellacani
Feb 16, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·A FarrohaO P Shelley
Apr 27, 2013·Expert Review of Anticancer Therapy·Aimilios LallasIris Zalaudek
Oct 15, 2013·The British Journal of Dermatology·A LallasI Zalaudek
Oct 26, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·Malou PeppelmanMarie-Jeanne P Gerritsen
Nov 26, 2013·Journal of the American Academy of Dermatology·Aimilios LallasGiuseppe Argenziano
Mar 19, 2014·Journal of the American Academy of Dermatology·Monica NapolitanoRiccardo Bono
Apr 1, 2014·Acta Dermato-venereologica·Stefania SeidenariGiovanni Ponti
Jun 15, 2014·Journal of the American Academy of Dermatology·Caterina LongoGiovanni Pellacani
Aug 16, 2014·Dermatology Practical & Conceptual·Aimilios LallasIris Zalaudek
Oct 24, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·R P CastroA Scope

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Citations

Oct 4, 2016·Dermatologic Clinics·Melissa Gill, Salvador González
Jan 25, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·C PezziniF Farnetani
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
May 1, 2019·Nature Biomedical Engineering·Dale J WaterhouseSarah E Bohndiek
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Mar 16, 2017·Journal of Cancer Research and Clinical Oncology·Yi-Quan XiongQing Chen
Aug 21, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C RuiniE C Sattler

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