PMID: 11926386Apr 3, 2002Paper

Non-invasive differentiation of pancreatic lesions: is analysis of FDG kinetics superior to semiquantitative uptake value analysis?

European Journal of Nuclear Medicine and Molecular Imaging
E NitzscheA Imdahl

Abstract

The diagnostic utility of fluorine-18 2-deoxy-D-glucose positron emission tomography (FDG PET) for the non-invasive differentiation of focal pancreatic lesions originating from cancer or chronic pancreatitis by combined visual image interpretation and semiquantitative uptake value analysis has been documented. However, in clinical routine some misdiagnosis is still observed. This is because there is potential overlap between the semiquantitative uptake values obtained for active inflammatory lesions and cancer. Therefore, this prospective study was undertaken to test the hypothesis that analysis of dynamic kinetics of focal pancreatic lesions based on FDG PET may more accurately determine the benign or malignant nature of such lesions. Thirty patients (56+/-17 years) were studied dynamically with FDG PET for a period of 60-90 min. Patients were assigned to one of four groups: control, acute pancreatitis, chronic pancreatitis or pancreatic cancer. Two observers, blinded to the clinical data, analysed the time-activity curves of FDG kinetics based on region of interest analysis. The diagnosis predicted by FDG PET was compared with the result of histological examination of the surgical specimen. Analysis of FDG kinetics revealed s...Continue Reading

Citations

Dec 31, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Tzu-Chen YenShu-Hang Ng
Mar 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ibane AbasoloFrancisco X Real
Mar 1, 2012·Cancer Biotherapy & Radiopharmaceuticals·Koen MertensIngeborg Goethals
Apr 22, 2003·AJR. American Journal of Roentgenology·Eric P TammDouglas B Evans
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Jan 20, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Gianpiero MancaDuccio Volterrani
Feb 14, 2006·Best Practice & Research. Clinical Gastroenterology·Bennett B Chin, Paul P L Chang
Apr 15, 2006·Expert Review of Anticancer Therapy·Rakesh Kumar, Anil Chauhan
Jan 19, 2017·Clinical Nuclear Medicine·Grace HennessyRobert Mansberg
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Dec 16, 2006·Radiología·C AyusoC de Juan

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