Non-invasive dural stimulation in mice: A novel preclinical model of migraine

Cephalalgia : an International Journal of Headache
Carolina Christina Burgos-VegaGreg Dussor

Abstract

Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the dura mater, the likely source of afferent signaling leading to head pain. The goal of this study was to determine whether dural stimulation can be performed in mice using an injection that does not cause injury or damage. Using mice, injections of stimuli were administered to the dura mater through the soft tissue at the intersection between the lambdoidal and sagittal sutures. This technique did not require a permanent cannula nor did it cause damage to the skull or dura. Following injection of noxious stimuli, migraine-like behaviors were measured including cutaneous allodynia and facial grimace. The retrograde tracer fluorogold was applied onto the dura using the same injection technique to label trigeminal ganglion cell bodies, which were then testing in vitro using patch-clamp electrophysiology. Dural injection of allyl-isothiocyanate, low pH, interleukin-6, or inflammatory soup but not vehicles, led to cephalic/extracephalic allodynia. Facial grimace responses were also observed with allyl-isothiocyanate, pH 6.0, ...Continue Reading

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Citations

Jan 1, 2020·European Journal of Pain : EJP·Sarah Louise ChristensenDavid M Kristensen
Aug 30, 2019·The Journal of Headache and Pain·Andrea M HarriottPhilip R Holland
Nov 3, 2020·Cephalalgia : an International Journal of Headache·Caroline M KopruszinskiFrank Porreca
Nov 18, 2020·Cephalalgia : an International Journal of Headache·Jacob LackovicGregory Dussor
Feb 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ömer KaradaşHayrunnisa Bolay
Oct 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosaria GrecoCristina Tassorelli
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Alexandra L WhittakerTimothy H Barker
May 28, 2021·Science Translational Medicine·Katelyn E SadlerCheryl L Stucky
Aug 29, 2021·Pharmaceuticals·Diéssica Padilha DalenogareGabriela Trevisan
Nov 25, 2021·Cephalalgia : an International Journal of Headache·Sarah L ChristensenDavid M Kristensen
Nov 28, 2021·Nature Reviews. Neuroscience·Katelyn E SadlerCheryl L Stucky

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Methods Mentioned

BETA
dissection

Software Mentioned

Origin
GPower
GraphPad Prism
pClamp
Clampfit
GraphPad

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