Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy

Biosensors & Bioelectronics
A CaduffYu Feldman

Abstract

The aim of this work was to evaluate the performance of a novel non-invasive continuous glucose-monitoring system based on impedance spectroscopy (IS) in patients with diabetes. Ten patients with type 1 diabetes (mean+/-S.D., age 28+/-8 years, BMI 24.2+/-3.2 kg/m(2) and HbA(1C) 7.3+/-1.6%) and five with type 2 diabetes (age 61+/-8 years, BMI 27.5+/-3.2 kg/m(2) and HbA(1C) 8.3+/-1.8%) took part in this study, which comprised a glucose clamp experiment followed by a 7-day outpatient evaluation. The measurements obtained by the NI-CGMD and the reference blood glucose-measuring techniques were evaluated using retrospective data evaluation procedures. Under less controlled outpatient conditions a correlation coefficient of r=0.640 and a standard error of prediction (SEP) of 45 mg dl(-1) with a total of 590 paired glucose measurements was found (versus r=0.926 and a SEP of 26 mg dl(-1) under controlled conditions). Clark error grid analyses (EGA) showed 56% of all values in zone A, 37% in B and 7% in C-E. In conclusion, these results indicate that IS in the used technical setting allows retrospective, continuous and truly non-invasive glucose monitoring under defined conditions for patients with diabetes. Technical advances and devel...Continue Reading

References

Jul 27, 2001·Diabetes Technology & Therapeutics·H Shamoon
May 17, 1957·Science·H P SCHWAN, E L CARSTENSEN

❮ Previous
Next ❯

Citations

Apr 14, 2007·Analytical and Bioanalytical Chemistry·Venkata Radhakrishna Kondepati, H Michael Heise
Jul 31, 2007·Medical & Biological Engineering & Computing·Daniel HuberAndreas Caduff
Jun 23, 2012·Medical & Biological Engineering & Computing·Mattia ZanonClaudio Cobelli
Feb 8, 2013·Chemical Reviews·Scott P NicholsMark H Schoenfisch
Jan 20, 2010·Diabetes Technology & Therapeutics·Andreas CaduffPavel Zakharov
Oct 19, 2007·Medical Engineering & Physics·Carlos Eduardo Ferrante do Amaral, Benhard Wolf
Jul 3, 2007·Biophysical Chemistry·A TuraG Pacini
Dec 5, 2006·Diabetes Research and Clinical Practice·Andrea TuraGiovanni Pacini
Jan 1, 2008·IEEE Reviews in Biomedical Engineering·Xiao-Fei TengPaolo Bonato
Sep 7, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Xuezhu ZhangTianfu Wu
Jan 28, 2017·Advanced Healthcare Materials·Shanshan YaoYong Zhu
Dec 7, 2010·Journal of Diabetes Science and Technology·Santhisagar VaddirajuFotios Papadimitrakopoulos
May 31, 2014·Journal of Diabetes Science and Technology·Sunsanee KanjananimmanontLeah Tolosa
Apr 26, 2015·Journal of Diabetes Science and Technology·Andreas CaduffMark S Talary
Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Andrea Tura
Feb 29, 2020·Sensors·Maryamsadat Shokrekhodaei, Stella Quinones
Jul 12, 2011·Physiological Measurement·F DewarratM S Talary
Jul 5, 2011·Journal of Diabetes Science and Technology·Martin MuellerAndreas Caduff
Sep 3, 2017·The Review of Scientific Instruments·A L NevesP Sabouroux
Oct 30, 2021·Journal of Diabetes Science and Technology·Farid SanaiThomas J Telfer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.