Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia

Brain : a Journal of Neurology
Lori C JordanManus J Donahue

Abstract

Sickle cell anaemia is a monogenetic disorder with a high incidence of stroke. While stroke screening procedures exist for children with sickle cell anaemia, no accepted screening procedures exist for assessing stroke risk in adults. The purpose of this study is to use novel magnetic resonance imaging methods to evaluate physiological relationships between oxygen extraction fraction, cerebral blood flow, and clinical markers of cerebrovascular impairment in adults with sickle cell anaemia. The specific goal is to determine to what extent elevated oxygen extraction fraction may be uniquely present in patients with higher levels of clinical impairment and therefore may represent a candidate biomarker of stroke risk. Neurological evaluation, structural imaging, and the non-invasive T2-relaxation-under-spin-tagging magnetic resonance imaging method were applied in sickle cell anaemia (n = 34) and healthy race-matched control (n = 11) volunteers without sickle cell trait to assess whole-brain oxygen extraction fraction, cerebral blood flow, degree of vasculopathy, severity of anaemia, and presence of prior infarct; findings were interpreted in the context of physiological models. Cerebral blood flow and oxygen extraction fraction we...Continue Reading

References

Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S VorstrupO B Paulson
Mar 1, 1992·The Journal of Pediatrics·B BalkaranG R Serjeant
Mar 1, 1991·Annals of Neurology·W J Powers
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Mar 11, 1998·Controlled Clinical Trials·R J AdamsM A Waclawiw
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·F O OrtizL J Benjamin
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Mar 2, 2002·Brain : a Journal of Neurology·Colin P DerdeynWilliam J Powers
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M van Zijl
Aug 9, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M van Zijl
Oct 25, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Michael R DebaunRobert C McKinstry
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason M ZhaoPeter C M van Zijl
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang Lu, Yulin Ge
Feb 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Isak ProhovnikSteven G Pavlakis
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng XuHanzhang Lu
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Gisele Sampaio SilvaAyrton Roberto Massaro
Jul 25, 2009·Stroke; a Journal of Cerebral Circulation·Rajat DharMichael N Diringer
Mar 6, 2010·Pediatric Hematology and Oncology·James F CasellaMichael R Debaun
Nov 6, 2010·Cerebral Cortex·Hanzhang LuDenise C Park
May 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter van Zijl
Jun 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D S BolarE Adalsteinsson
Nov 15, 2011·Expert Review of Hematology·John J StrouseVictor Urrutia
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yulin GeRobert I Grossman
Feb 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jia Guo, Eric C Wong
Jun 29, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Feng XuHanzhang Lu
Jul 12, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lisa C KrishnamurthyHanzhang Lu
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
Apr 24, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carlos C FaracoManus J Donahue
May 2, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahueJeroen C W Siero
Aug 12, 2014·Blood·Monica L Hulbert, Andria L Ford
Feb 28, 2015·Stroke; a Journal of Cerebral Circulation·Hongyu AnWeili Lin

❮ Previous
Next ❯

Citations

Dec 29, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jennifer M WatchmakerManus J Donahue
Jun 7, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Deng MaoHanzhang Lu
Dec 2, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam M BushJohn C Wood
Dec 23, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhiliang WeiHanzhang Lu
Jan 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yayan YinJia-Hong Gao
Jan 26, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dengrong JiangHanzhang Lu
Aug 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahueJeroen Hendrikse
Apr 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lori C Jordan, Michael R DeBaun
Oct 17, 2018·Journal of Magnetic Resonance Imaging : JMRI·Meher R JuttukondaLori C Jordan
Jan 22, 2019·Stroke; a Journal of Cerebral Circulation·Kristin P GuilliamsMichael M Dowling
Jan 22, 2019·Stroke; a Journal of Cerebral Circulation·Manus J DonahueLori C Jordan
Oct 18, 2018·Annual Review of Pathology·Prithu SunddEnrico M Novelli
Mar 7, 2019·American Journal of Hematology·Lori C JordanManus J Donahue
Dec 10, 2017·Hematology·Elliott Vichinsky
May 28, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Caitlin O'BrienPeter Jezzard
Nov 6, 2018·Journal of Magnetic Resonance Imaging : JMRI·Christopher LeatherdayDeqiang Qiu
Mar 3, 2018·Blood·John C Wood
Jan 11, 2020·American Journal of Hematology·Lena VáclavůBart J Biemond
May 13, 2018·Neurology·Hanne StotesburyJamie M Kawadler
Nov 10, 2017·Neurology·Angela L JeffersonManus J Donahue
Mar 4, 2018·Neurology·Hanne StotesburyFenella J Kirkham
Jul 10, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dengrong JiangHanzhang Lu
Dec 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Meher R JuttukondaLori C Jordan
Apr 14, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Meher R JuttukondaLori C Jordan
Sep 3, 2019·Frontiers in Neurology·Hanne StotesburyFenella J Kirkham
Aug 7, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dengrong JiangHanzhang Lu
Sep 2, 2020·Annals of Neurology·Melanie E FieldsJin-Moo Lee
Jul 8, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam BushJohn C Wood
Jun 30, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xin MiaoJohn C Wood
Sep 27, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Emily A MorrisLori C Jordan
Nov 20, 2016·British Journal of Haematology·Michael M Dowling, Fenella J Kirkham
Jan 22, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cihat EldenizHongyu An
May 12, 2020·American Journal of Hematology·Tonner DeBeerManus J Donahue
Feb 4, 2021·American Journal of Hematology·Kristine KarkoskaPatrick T McGann
Feb 23, 2021·Expert Review of Hematology·Hanne StotesburyFenella Jane Kirkham
Mar 16, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam BushJohn C Wood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Related Papers

AJNR. American Journal of Neuroradiology
A M WinchellK J Helton
The Tohoku Journal of Experimental Medicine
Ismet MelekEdip Gali
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
N A Lassen
© 2021 Meta ULC. All rights reserved