Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Frontiers in Oncology
Lorena ConsolinoDario Livio Longo

Abstract

Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.

References

Sep 23, 2000·Nature·P Carmeliet, R K Jain
Aug 9, 2002·Journal of the American Chemical Society·Silvio AimeEnzo Terreno
Sep 5, 2002·Nature Reviews. Cancer·Sanjiv Sam Gambhir
Oct 28, 2003·Journal of Magnetic Resonance Imaging : JMRI·Susan K HobbsMark D Bednarski
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M van Zijl
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Silvio AimeEnzo Terreno
Mar 25, 2006·Future Oncology·Angelo De Milito, Stefano Fais
Aug 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Craig K JonesJinyuan Zhou
Nov 30, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Phillip Zhe SunPeter C M van Zijl
Oct 11, 2007·NMR in Biomedicine·Amandeep SalhotraJinyuan Zhou
Nov 27, 2008·The Journal of Clinical Investigation·Gregg L Semenza
Nov 27, 2008·The Journal of Clinical Investigation·Pierre SonveauxMark W Dewhirst
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W Thomas DixonA Dean Sherry
Sep 11, 2010·Acta Radiologica·Ileana HancuRobert E Lenkinski
Oct 16, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dario Livio LongoSilvio Aime
Feb 1, 2011·Methods in Molecular Biology·Jinyuan Zhou
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter C M van Zijl, Nirbhay N Yadav
Mar 3, 2011·Seminars in Oncology·Kristine Glunde, Zaver M Bhujwalla
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Guang JiaMichael V Knopp
Sep 17, 2011·Nature Reviews. Drug Discovery·Dario Neri, Claudiu T Supuran
Oct 27, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vipul R ShethMark D Pagel
Aug 22, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adrienne N DulaSeth A Smith
Oct 13, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dario Livio LongoSilvio Aime
Oct 18, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kannie W Y ChanPeter C M van Zijl
Jan 1, 2013·Journal of Magnetic Resonance·Elena VinogradovRobert E Lenkinski
Jan 5, 2013·Cancer Research·Veronica EstrellaRobert J Gillies
Jan 11, 2013·NMR in Biomedicine·Guanshu LiuMichael T McMahon
Feb 20, 2013·Journal of Cell Science·Frances R BalkwillThorsten Hagemann
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Alessandra VialeSilvio Aime
Mar 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D Delli CastelliSilvio Aime
May 16, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fatima A NasrallahKai-Hsiang Chuang
Jul 9, 2013·Nature Medicine·Simon Walker-SamuelXavier Golay
Nov 28, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Liu Qi ChenMark D Pagel
Dec 5, 2013·Molecular Cancer·Shanmugasundaram Ganapathy-Kanniappan, Jean-Francois H Geschwind
Jan 2, 2014·Frontiers in Physiology·Mehdi DamaghiRobert J Gillies
Feb 27, 2014·Magma·Anja Müller-LutzHans-Jörg Wittsack
Jun 17, 2014·Seminars in Radiation Oncology·Masayuki MatsuoKevin Camphausen
Sep 23, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michal RivlinGil Navon

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Citations

Oct 9, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daisy VillanoDario Livio Longo
Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann
Sep 29, 2020·The Proceedings of the Nutrition Society·Paul A M SmeetsMorwarid Mayar
Dec 2, 2020·British Journal of Cancer·Annasofia AnemoneDario Livio Longo
Dec 12, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·M P MertsalovaP V Rodionov
Feb 10, 2021·Biomedicines·Meredith A JonesLacey R McNally
Mar 26, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lorena ConsolinoDario Livio Longo
May 14, 2021·Molecular Therapy Oncolytics·Susanna C ConcilioKah-Whye Peng
Jul 24, 2021·Current Opinion in Chemical Biology·Peter C M van ZijlLinda Knutsson
Aug 13, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martina CapozzaSilvio Aime

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Methods Mentioned

BETA
chemical exchange saturation transfer
xenograft
imaging technique
chemical exchange
X-ray
xenografts
Magnetic

Software Mentioned

PARACEST
DIACEST
GlucoCEST

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