Non-invasive Low-Intensity Pulsed Ultrasound Modulates Primary Cilia of Rat Hippocampal Neurons

Ultrasound in Medicine & Biology
Xiaowei HuangLili Niu

Abstract

Transcranial modulation of primary cilia may provide new opportunities in the treatment of neurodegenerative diseases. This study investigates the effect of non-invasive low-intensity pulsed ultrasound (LIPUS) stimulation on primary cilia of rat hippocampal neurons. Three hours of LIPUS stimulation significantly reduced the incidence rate and length of cilia on cultured neurons (p < 0.01). Similarly, increasing the duration and intensity of LIPUS stimulation decreased the incidence and length of cilia. LIPUS stimulation improved c-fos expression when it was delivered to CA1 of the intact hippocampus of rats. And prolonged LIPUS stimulation (frequency: 0.5 MHz, pulse repetition frequency: 500 Hz, duty cycle: 5%, Ispta: 255 mW/cm2, 10 min/d, 10 d) caused a statistically significant reduction in the incidence rate (p < 0.05) and length of primary cilia (p < 0.01) of neurons in rat CA1 hippocampus. These results indicate the promising potential of LIPUS stimulation in the treatment of primary cilium-related brain diseases.

Citations

May 7, 2021·Research : a Science Partner Journal·Tianyuan BianHairong Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Ni DongFeng Deng
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Hongbin LüLing Qin
© 2022 Meta ULC. All rights reserved