PMID: 8589352Jan 1, 1995Paper

Non-invasive means to study the functional status of sinusoidal liver endothelial cells

Journal of Gastroenterology and Hepatology
B Smedsrød

Abstract

Circulating connective tissue macromolecules are efficiently eliminated by receptor-mediated endocytosis in liver endothelial cells (LEC). In patients with a seriously diseased liver, for example in liver cirrhosis or when a transplanted liver is about to be rejected, dysfunctional LEC or altered blood perfusion through the liver results in significantly increased serum levels of connective tissue macromolecules and other substances that are normally taken up by LEC. With the aid of high affinity antibodies or other kinds of binding proteins it has been possible to measure a number of connective tissue macromolecules in the blood, and some of these substances have been used to diagnose serious liver disease. However, the metabolic patterns of these molecules are such that it is difficult to extrapolate directly on the basis of increased serum levels to conclude that the main underlying cause of increased serum levels is dysfunctional LEC. Elevated serum levels of many connective tissue proteins may reflect either increased synthesis, increased release from cell or tissue depots, and/or decreased removal by LEC. Therefore, to use measurement of serum connective tissue molecule levels as indicators of LEC function, it is imperati...Continue Reading

References

Dec 1, 1979·European Journal of Clinical Investigation·H RohdeR Timpl
Mar 1, 1990·The Biochemical Journal·B SmedsrødT C Laurent
Mar 1, 1989·Transplantation·D H AdamsJ M Neuberger
Aug 1, 1989·Pharmaceutical Research·L LebelT C Laurent
Nov 1, 1988·Acta Physiologica Scandinavica·R K ReedT C Laurent
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergL Lööf
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T FrébourgJ Bourreille
Jun 1, 1986·The Biochemical Journal·A TengbladT C Laurent
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·A Engström-LaurentT C Laurent
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Engström-LaurentT Schröder
Jan 1, 1985·Cell and Tissue Research·J R FraserG B Ryan
Jan 1, 1984·Clinical and Experimental Pharmacology & Physiology·J R FraserU G Laurent
Sep 1, 1994·European Journal of Clinical Investigation·L LebelB Gerdin

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Citations

Dec 4, 2003·Journal of Hepatology·Thomas KörnerAxel M Gressner
Oct 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Xupeng GeSuchitra Sumitran-Holgersson

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