Non-invasive measurement of biochemical profiles in the healthy fetal brain.

NeuroImage
Subechhya PradhanCatherine Limperopoulos

Abstract

Proton magnetic resonance spectroscopy (1H-MRS) of the fetal brain can be used to study emerging metabolite profiles in the developing brain. Identifying early deviations in brain metabolic profiles in high-risk fetuses may offer important adjunct clinical information to improve surveillance and management during pregnancy. To investigate the normative trajectory of the fetal brain metabolites during the second half of gestation, and to determine the impact of using different Cramer-Rao Lower Bounds (CRLB) threshold on metabolite measurements using magnetic resonance spectroscopy. We prospectively enrolled 219 pregnant women with normal fetal ultrasound and biometric measures. We performed a total of 331 fetal 1H-MRS studies with gestational age in the rage of 18-39 weeks with 112 of the enrolled participants scanned twice. All the spectra in this study were acquired on a GE 1.5 T scanner using long echo-time of 144 ​ms and analyzed in LCModel. We successfully acquired and analyzed fetal 1H-MRS with a success rate of 93%. We observed increases in total NAA, total creatine, total choline, scyllo inositol and total NAA-to-total choline ratio with advancing GA. Our results also showed faster increases in total NAA and total NAA-to...Continue Reading

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Citations

Jan 22, 2021·Acta Paediatrica·Ariunzaya AmgalanCatherine Limperopoulos
Sep 26, 2021·Experimental Neurology·Nickie Andescavage, Catherine Limperopoulos
Dec 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Josepheen De Asis-CruzCatherine Limperopoulos

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Methods Mentioned

BETA
sedation

Software Mentioned

LCModel
Scyllo
Matlab

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