Non-invasive monitoring of skin inflammation using an oxygen-sensing paint-on bandage

Biomedical Optics Express
Zongxi LiConor L Evans

Abstract

Inflammation involves a cascade of cellular and molecular mediators that ultimately lead to the infiltration of immune cells into the affected area. This inflammatory process in skin is common to many diseases including acne, infection, and psoriasis, with the presence or absence of immune cells a potential diagnostic marker. Here we show that skin inflammation can be non-invasively measured and mapped using a paint-on oxygen sensing bandage in an in vivo porcine inflammation model. After injection of a known inflammatory agent, the bandage could track the increase, plateau, and decrease in oxygen consumption at the injury site over 7 weeks, as well as discern inflammation resultant from injection at various depths beneath the surface of the skin. Both the initial rate of pO2 change and the change in bandage pO2 at equilibration (CBP20) were found to be directly related to the metabolic oxygen consumption rate of the tissue in contact. Healthy skin demonstrated an initial pO2 decrease rate of 6.5 [Formula: see text], and CBP20 of 84 [Formula: see text]. Inflamed skin had a significantly higher initial consumption rate of 55 [Formula: see text], and a larger CBP20 of 140 [Formula: see text]. The change in the bandage pO2 before ...Continue Reading

References

Jan 1, 1995·Archives of Dermatological Research·Y YoshinagaM Kawashima
Oct 6, 2001·Journal of Clinical Gastroenterology·A L Buchman
Nov 14, 2007·Methods in Enzymology·Stilla FredeJoachim Fandrey
Mar 3, 2009·Angewandte Chemie·Changfeng WuJason McNeill
Jan 15, 2010·ACS Applied Materials & Interfaces·Artem Y LebedevSergei A Vinogradov
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas J KominskySean P Colgan
Apr 9, 2010·Journal of the American Chemical Society·Michael B WinterMichael A Marletta
Mar 25, 2014·Annual Review of Immunology·Michelle A LowesJames G Krueger
Apr 12, 2014·Nature Reviews. Immunology·Manolis PasparakisFrank O Nestle
Oct 30, 2015·Angewandte Chemie·Emmanuel RoussakisConor L Evans

❮ Previous
Next ❯

Citations

Oct 3, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maciej M KmiecPeriannan Kuppusamy
Dec 24, 2019·Photochemistry and Photobiology·Emmanuel RoussakisConor L Evans
Jul 24, 2020·Advances in Skin & Wound Care·Daniel Naveed TavakolPatrick S Cottler
Jul 24, 2018·International Journal of Inflammation·Nalú Navarro-AlvarezChristene A Huang
Dec 29, 2018·Journal of Biomedical Optics·Zongxi LiGabriela Apiou-Sbirlea
Aug 11, 2019·Nature Communications·Januka Budhathoki-UpretyDaniel A Heller
Jan 8, 2021·Biomedical Optics Express·Juan Pedro CascalesConor L Evans
May 18, 2019·Biomaterials·Emmanuel RoussakisXiomara Calderón-Colón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Family Physician Médecin De Famille Canadien
Benjamin Barankin, Joel DeKoven
British Medical Journal
G M Murphy, M W Greaves
European Journal of Pharmacology
P A Henricks, F P Nijkamp
© 2022 Meta ULC. All rights reserved