Non-invasive Neuromodulation of Spinal Cord Restores Lower Urinary Tract Function After Paralysis

Frontiers in Neuroscience
Parag N GadV Reggie Edgerton

Abstract

It is commonly assumed that restoration of locomotion is the ultimate goal after spinal cord injury (SCI). However, lower urinary tract (LUT) dysfunction is universal among SCI patients and significantly impacts their health and quality of life. Micturition is a neurologically complex behavior that depends on intact sensory and motor innervation. SCI disrupts both motor and sensory function and leads to marked abnormalities in urine storage and emptying. Current therapies for LUT dysfunction after SCI focus on preventing complications and managing symptoms rather than restoring function. In this study, we demonstrate that Transcutaneous Electrical Spinal Stimulation for LUT functional Augmentation (TESSLA), a non-invasive neuromodulatory technique, can reengage the spinal circuits' active in LUT function and normalize bladder and urethral sphincter function in individuals with SCI. Specifically, TESSLA reduced detrusor overactivity (DO), decreased detrusor-sphincter dyssynergia (DSD), increased bladder capacity and enabled voiding. TESSLA may represent a novel approach to transform the intrinsic spinal networks to a more functionally physiological state. Each of these features has significant clinical implications. Improvement ...Continue Reading

Associated Clinical Trials

References

Jul 1, 1991·The Journal of Urology·S A KaplanJ G Blaivas
Jan 14, 1998·Urology·W C de Groat
Dec 16, 1998·Spinal Cord·A GiannantoniG Vespasiani
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura
Jan 28, 2005·Journal of Neurotrauma·Kim D Anderson
Oct 4, 2005·Progress in Brain Research·Robert A Gaunt, Arthur Prochazka
Sep 22, 2009·Nature Neuroscience·Grégoire CourtineV Reggie Edgerton
Dec 22, 2009·Neurourology and Urodynamics·William C de Groat, Naoki Yoshimura
Feb 27, 2010·Annals of Neurology·Karl-Dietrich SievertArnulf Stenzl
Dec 1, 2012·Journal of Veterinary Internal Medicine·N GrangerN D Jeffery
Dec 18, 2013·Journal of Neurophysiology·Dimitry G SayenkoYury P Gerasimenko
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Edsel M AbudHuiyi H Chang
Mar 31, 2015·Journal of Applied Physiology·Dimitry G SayenkoYury P Gerasimenko
Jun 17, 2015·Journal of Neurotrauma·Yury P GerasimenkoV Reggie Edgerton
Oct 25, 2016·Experimental Neurology·Parag N GadV Reggie Edgerton
Apr 14, 2018·Journal of Neurotrauma·Parag GadV Reggie Edgerton
May 23, 2018·Journal of Neurotrauma·Mrinal RathDimitry G Sayenko
Jun 8, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Fatma InaniciChet T Moritz

❮ Previous
Next ❯

Citations

Aug 28, 2019·Tissue Engineering. Part B, Reviews·Nureddin AshammakhiStephanie K Seidlits
Aug 7, 2020·Journal of Neurophysiology·Parag GadV Reggie Edgerton
Oct 19, 2019·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·A A SavenkovaT R Moshonkina
Aug 6, 2020·Healthcare Technology Letters·Casey J Steadman, Warren M Grill
Aug 11, 2020·Frontiers in Systems Neuroscience·Yuriy SysoevPavel Musienko
Mar 3, 2020·Frontiers in Systems Neuroscience·Evgeniy KreydinParag Gad
Nov 10, 2020·Frontiers in Systems Neuroscience·Polina ShkorbatovaPavel Musienko
Jul 6, 2021·Neurotrauma Reports·Parag GadEvgeniy Kreydin
Jul 11, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Parag GadV Reggie Edgerton
Aug 15, 2021·Autonomic Neuroscience : Basic & Clinical·Sergei Karnup

❮ Previous
Next ❯

Methods Mentioned

BETA
urine storage

Software Mentioned

Graphpad
TESSLA On
TESSLA
TESSLA Off

Related Concepts

Related Feeds

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.