Non-Invasive Prediction of IDH Mutation in Patients with Glioma WHO II/III/IV Based on F-18-FET PET-Guided In Vivo 1 H-Magnetic Resonance Spectroscopy and Machine Learning

Cancers
Elisabeth BumesMarkus Hutterer

Abstract

Isocitrate dehydrogenase (IDH)-1 mutation is an important prognostic factor and a potential therapeutic target in glioma. Immunohistological and molecular diagnosis of IDH mutation status is invasive. To avoid tumor biopsy, dedicated spectroscopic techniques have been proposed to detect D-2-hydroxyglutarate (2-HG), the main metabolite of IDH, directly in vivo. However, these methods are technically challenging and not broadly available. Therefore, we explored the use of machine learning for the non-invasive, inexpensive and fast diagnosis of IDH status in standard 1H-magnetic resonance spectroscopy (1H-MRS). To this end, 30 of 34 consecutive patients with known or suspected glioma WHO grade II-IV were subjected to metabolic positron emission tomography (PET) imaging with O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) for optimized voxel placement in 1H-MRS. Routine 1H-magnetic resonance (1H-MR) spectra of tumor and contralateral healthy brain regions were acquired on a 3 Tesla magnetic resonance (3T-MR) scanner, prior to surgical tumor resection and molecular analysis of IDH status. Since 2-HG spectral signals were too overlapped for reliable discrimination of IDH mutated (IDHmut) and IDH wild-type (IDHwt) glioma, we used a nested ...Continue Reading

References

Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 1, 2006·BMC Bioinformatics·Sudhir Varma, Richard Simon
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Jun 25, 2009·Analytical Chemistry·Wolfram GronwaldPeter J Oefner
Nov 12, 2009·Brain Pathology·David CapperAndreas von Deimling
Jul 27, 2011·Nuklearmedizin. Nuclear Medicine·K-J LangenM Schreckenberger
Sep 4, 2013·The Journal of Clinical Investigation·Ovidiu C AndronesiBruce R Rosen
Mar 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fumiharu OhkaAtsushi Natsume
Jul 22, 2014·Nature·Theresa SchumacherMichael Platten
Mar 31, 2015·Der Pathologe·W DietmaierM J Riemenschneider
May 20, 2015·Oncotarget·Elisabet CuyàsJavier A Menendez
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Mar 23, 2017·Scientific Reports·Llewellyn E JalbertSarah J Nelson
Oct 19, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Antoine VergerNorbert Galldiks
Jan 10, 2018·NMR in Biomedicine·Adam BerringtonUzay E Emir
Sep 8, 2018·Scientific Reports·Philipp LohmannNorbert Galldiks
Jun 6, 2019·Frontiers in Oncology·Danielle GolubDimitris G Placantonakis
Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Franziska VettermannNathalie L Albert
Feb 15, 2020·Neuro-oncology·Vivek TiwariChangho Choi
Jul 14, 2020·Current Opinion in Neurology·Francesca Branzoli, Małgorzata Marjańska

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
nuclear magnetic resonance
NMR
biopsy

Software Mentioned

jMRUI
script
R
code

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gan to kagaku ryoho. Cancer & chemotherapy
Akitake Mukasa
Clinical Lymphoma, Myeloma & Leukemia
Stéphane de Botton
Expert Review of Molecular Diagnostics
Alberto PiccaMarc Sanson
© 2021 Meta ULC. All rights reserved