Non-invasive quantification of hepatic fat content in healthy dogs by using proton magnetic resonance spectroscopy and dual gradient echo magnetic resonance imaging

Journal of Veterinary Science
Francesca Del ChiccaPatrick R Kircher

Abstract

The objective of the present study was to describe two non-invasive methods for fat quantification in normal canine liver by using magnetic resonance imaging (MRI) and spectroscopy. Eleven adult beagle dogs were anesthetized and underwent magnetic resonance examination of the cranial abdomen by performing morphologic, modified Dixon (mDixon) dual gradient echo sequence, and proton magnetic resonance spectroscopy (1H MRS) imaging. In addition, ultrasonographic liver examination was performed, fine-needle liver aspirates and liver biopsies were obtained, and hepatic triglyceride content was assayed. Ultrasonographic, cytologic, and histologic examination results were unremarkable in all cases. The median hepatic fat fraction calculated was 2.1% (range, 1.3%-5.5%) using mDixon, 0.3% (range, 0.1%-1.0%) using 1H MRS, and 1.6% (range 1.0%-2.5%) based on triglyceride content. The hepatic fat fractions calculated using mDixon and 1H MRS imaging were highly correlated to that based on triglyceride content. A weak correlation between mDixon and 1H MRS imaging was detected. The results show that hepatic fat content can be estimated using non-invasive techniques (mDixon or 1H MRS) in healthy dogs. Further studies are warranted to evaluate ...Continue Reading

References

Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Sep 8, 2000·American Journal of Veterinary Research·W T DrostT W Lehenbauer
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Dec 6, 2005·The Journal of Veterinary Medical Science·Momoko NakamuraToshiroh Iwasaki
Jan 27, 2007·Radiology·Antonio C A WestphalenFergus V Coakley
Feb 5, 2008·American Journal of Veterinary Research·Daniel A FeeneyRobert M Hardy
Jan 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sameer M MazharClaude B Sirlin
Jun 16, 2009·The Veterinary Clinics of North America. Small Animal Practice·Lorrie Gaschen
Oct 1, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Martin GuillotJérôme R E Del Castillo
Oct 13, 2009·Journal of Computer Assisted Tomography·Nicolas MennessonFrank Pilleul
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aliya Qayyum
Dec 17, 2009·Topics in Magnetic Resonance Imaging : TMRI·William H PermanIsin Akduman
Apr 1, 2010·World Journal of Gastroenterology : WJG·Fabian SpringerNina F Schwenzer
Apr 20, 2010·European Journal of Radiology·Hersh Chandarana, Bachir Taouli
Jun 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·H A MarsmanT M van Gulik
Jan 8, 2011·Radiology·Takeshi YokooClaude B Sirlin
May 4, 2013·Research in Veterinary Science·M H ClarkM Hoenig
Jun 20, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Alyce L MarksKatherine H Deanna
Jan 13, 2015·Journal of Veterinary Internal Medicine·S D KempM S Leib

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Citations

Sep 25, 2020·American Journal of Veterinary Research·Gian-Luca StegerFrancesca Del Chicca

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Methods Mentioned

BETA
biopsy
biopsies
imaging techniques

Software Mentioned

SPSS Statistics
MR WorkSpace
LCModel
Extended

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