Non-invasive quantitative pulmonary V/Q imaging using Fourier decomposition MRI at 1.5T

Zeitschrift für medizinische Physik
Åsmund KjørstadLothar R Schad

Abstract

Techniques for quantitative pulmonary perfusion and ventilation using the Fourier Decomposition method were recently demonstrated. We combine these two techniques and show that ventilation-perfusion (V/Q) imaging is possible using only a single MR acquisition of less than thirty seconds. The Fourier Decomposition method is used in combination with two quantification techniques, which extract baselines from within the images themselves and thus allows quantification. For the perfusion, a region assumed to consist of 100% blood is utilized, while for the ventilation the zero-frequency component is used. V/Q-imaging is then done by dividing the quantified ventilation map with the quantified perfusion map. The techniques were used on ten healthy volunteers and fifteen patients diagnosed with lung cancer. A mean V/Q-ratio of 1.15 ± 0.22 was found for the healthy volunteers and a mean V/Q-ratio of 1.93 ± 0.83 for the non-afflicted lung in the patients. Mean V/Q-ratio in the afflicted (tumor-bearing) lung was found to be 1.61 ± 1.06. Functional defects were clearly visible in many of the patient images, but 5 of 15 patient images had to be excluded due to artifacts or low SNR, indicating a lack of robustness. Non-invasive, quantitativ...Continue Reading

References

May 1, 1983·AJR. American Journal of Roentgenology·E R BankD R Dantzker
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J CardúsP D Wagner
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·R J GilliesN Raghunand
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vu M MaiQun Chen
Feb 10, 2006·Physics in Medicine and Biology·Thomas GuerreroRitsuko Komaki
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz BaumanLothar R Schad
Oct 6, 2010·Seminars in Nuclear Medicine·Elizabeth A BaileyPaul J Roach
Aug 3, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paul J RoachDale L Bailey
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Åsmund KjørstadLothar R Schad

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Citations

Aug 16, 2016·Zeitschrift für medizinische Physik·Åsmund KjørstadJan Sedlacik
Sep 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andreas VoskrebenzevJens Vogel-Claussen
Jun 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jascha ZappLothar R Schad
Oct 16, 2020·Journal of Magnetic Resonance Imaging : JMRI·Gesa H PöhlerJens Vogel-Claussen
Apr 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julian GlandorfJens Vogel-Claussen
Jul 30, 2021·NMR in Biomedicine·Anke BalaschVolker Rasche

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