Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Gunnar WaterstraatGabriel Curio

Abstract

Somatosensory evoked potentials (SEPs) around 600 Hz ('σ-bursts') are correlates of cortical population spikes. Recently, single-trial σ-bursts were detected in human scalp EEG using 29-channel low-noise recordings in an electromagnetically shielded room. To achieve clinical applicability, this study aimed to establish a protocol using only 8 EEG channels in an unshielded environment and to quantify the variability of σ-bursts. Median nerve SEPs were recorded in 10 healthy subjects using a custom-built low-noise EEG amplifier. A detection algorithm for single-trial σ-bursts was trained as combination of spatio-temporal filters and a non-linear classifier. The single-trial responses were probed for the presence of significant increases of amplitude and variability. Single-trial σ-burst detection succeeded with Detection Rates and Positive Predictive Values above 80% in subjects with high SNR. A significant inter-trial variability in the amplitudes of early low-frequency SEPs and σ-bursts could be demonstrated. Single-trial σ-bursts can be detected on scalp-EEG using only 8 EEG channels in an electromagnetically disturbed environment. The combination of dedicated hardware and detection algorithms allows quantifying and describing...Continue Reading

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Citations

Jan 19, 2017·Physiological Measurement·Nawel JmailChristian-G Bénar
May 19, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tommaso FedeleJohannes Sarnthein
Mar 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Gunnar WaterstraatGabriel Curio

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