Abstract
Although well-defined clinically and electrocardiographically, Acquired Long QT Syndrome (LQTS) remains elusive from a pathophysiologic point of view. An increasingly accepted hypothesis is that it represents an attenuated form of Congenital Long QT Syndrome. To test this hypothesis further, we investigated patients with Acquired LQTS, using various investigations that are known to give information in patients with Congenital LQTS. All the investigations were performed in patients with a history of Acquired Long QT Syndrome, defined by marked transient QT lengthening (QT>600 ms) and/or torsades de pointes. Measurement of the QT interval dispersion, the interlead difference for the QT interval on a 12-lead ECG, was performed in 18 patients and compared with 18 controls, matched for age and sex. To assess sympathetic myocardial innervation, I-123 Meta-iodobenzylguanidine (I-123-MIBG) scintigraphy was performed in 12 patients, together with Thallium scintigraphy, to rule out abnormal myocardial perfusion. Time-frequency analysis of a high-resolution ECG using a wavelet technique, was made for nine patients and compared with 38 healthy controls. Finally, genetic studies were performed prospectively in 16 consecutive patients, to lo...Continue Reading
Citations
Jun 22, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter KiesEric Schulze-Bahr
Jul 14, 2005·International Journal of Legal Medicine·Horst WedekindEric Schulze-Bahr
Aug 10, 2002·Current Cardiology Reports·Mackenzi MbaiCraig T January
Nov 1, 2007·Nature Reviews. Drug Discovery·Russell A WilkeRonald M Krauss
Feb 21, 2003·British Journal of Anaesthesia·P D BookerE J Ladusans
Mar 24, 2004·Journal of Neurosurgery·Shingo ToyotaToshiki Yoshimine
Nov 13, 2013·Cardiovascular Journal of Africa·Paula L HedleyValerie A Corfield
Oct 25, 2012·Case Reports in Medicine·A TounsiS Kammoun
May 1, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Annukka LehtonenHeikki Swan
Feb 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Philippe ChevalierClaire Rodriguez-Lafrasse
Sep 2, 2009·Biophysical Journal·Frank S ChoveauGildas Loussouarn
Jul 20, 2005·International Journal of Cardiology·Haran BurriPaul Touboul
Jan 13, 2006·Journal of Cardiovascular Electrophysiology·Ngai-Shing MokChing-Wan Lam
Dec 18, 2013·Gene·Asma MechakraGeorges Christé
Apr 9, 2009·Progress in Biophysics and Molecular Biology·Eric Schulze-Bahr
Feb 11, 2015·The American Journal of Cardiology·Zachary LaksmanAndrew D Krahn
May 24, 2011·Korean journal of anesthesiology·Jae-Young LeePyung Hwan Park
Jan 25, 2006·Circulation·Corey L AndersonCraig T January
Jan 24, 2007·Anesthesia and Analgesia·Simon D WhytePeter D Booker
Aug 10, 2005·Physiological Measurement·Paul S Addison
Aug 21, 2008·Anesthesia and Analgesia·Helen V Hume-SmithSimon D Whyte
Sep 3, 2017·Heart·Sven ZumhagenEric Schulze-Bahr
Jan 15, 2015·Anesthesiology·Ikuomi MikuniWai-Meng Kwok
Jun 5, 2004·Annals of Medicine·Marc A Vos, Aimée D C Paulussen
Jun 21, 2021·JACC. Cardiovascular Imaging·Elizabeth L PotterThomas H Marwick