Non-invasive vagus nerve stimulation (nVNS) as symptomatic treatment of migraine in young patients: a preliminary safety study

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
L GrazziP Barbanti

Abstract

Recent clinical experiences and clinical trials have demonstrated the safety, tolerability, and efficacy of non-invasive vagus nerve stimulation (nVNS; gammaCore®) for the acute and prophylactic treatment of migraine. nVNS has a favorable adverse event profile, making it an attractive option for sensitive patient populations. We explored the safety, tolerability, and efficacy of nVNS as acute migraine treatment in adolescents. A group of adolescent patients suffering from migraine without aura were trained to use gammaCore to manage their migraine attacks. 46.8% of the treated migraine attacks (22/47) were considered successfully treated and did not require any rescue medication. No device-related adverse events were recorded. This preliminary study suggests that nVNS may represent a safe, well-tolerated, and effective for acute migraine treatment in adolescents.

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Citations

Oct 18, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Jessica TarnWan-Fai Ng
May 6, 2019·Expert Review of Neurotherapeutics·János TajtiLászló Vécsei
Jul 10, 2019·Current Pain and Headache Reports·Alan David KayeRichard D Urman
Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
Jul 29, 2020·Cephalalgia : an International Journal of Headache·Stephen D SilbersteinHans-Christoph Diener
Feb 23, 2019·Cephalalgia : an International Journal of Headache·Dylan Jozef Hendrik Augustinus HenssenKris Vissers
Mar 14, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yin-Hsuan LaiChiehfeng Chen
Dec 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A Yu SokolovA V Amelin
Jun 24, 2021·Headache·Jessica AilaniUNKNOWN Board of Directors of the American Headache Society
Jun 22, 2021·Anesthesiology and Pain Medicine·Ivan UritsOmar Viswanath
Aug 13, 2021·Frontiers in Immunology·Kristen Davies, Wan-Fai Ng

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