Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke

Brain Stimulation
Yirong YangYi Yang

Abstract

Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the blood-brain barrier (BBB), leading to reduced infarct size in ischemic brain. Spontaneous hypertensive rats (SHRs) were subjected to a 90 min MCAO. nVNS treated rats received 5 stimulations (duration: 2 min; every 10 min) on the skin overlying the cervical vagus nerve in the neck beginning 30 min after MCAO onset. Control rats received the same stimulations on the quadriceps femoris muscle. Twenty-four hours after MCAO onset, MRI and immunohistochemistry (IHC) were performed for analyses of infarct size and BBB leakage. Compared with the control group, anatomic MRI T2-weighted images showed significantly smaller infarct sizes in the nVNS group. Dynamic contrast-enhanced (DCE)-MRI showed a significantly decreased BBB transfer rate (Ki map) in the lesion area in the nVNS group, which was spatially correlated with the attenuation of the infarct size. Furthermore, significantly lower serum IgG leakage, visualized by IHC, was seen in the ische...Continue Reading

Citations

Feb 13, 2019·Reviews in the Neurosciences·Elnaz AmanzadehMaryam Nourbakhshnia
Apr 5, 2019·Stroke; a Journal of Cerebral Circulation·Tomoaki SuzukiCenk Ayata
Jul 29, 2020·Cephalalgia : an International Journal of Headache·Stephen D SilbersteinHans-Christoph Diener
Sep 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laurel O SillerudYi Yang
May 12, 2020·The Journal of Clinical Investigation·Costantino IadecolaJosef Anrather
Aug 25, 2019·Neurochemistry International·Jingxi MaZhiyou Cai
Dec 12, 2020·Neurochemistry International·Yoshihiko Kakinuma
Apr 15, 2020·Brain Stimulation·Devin AdairMarom Bikson
Mar 4, 2021·International Journal of Molecular Sciences·Angelica CarandinaEleonora Tobaldini
Feb 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yu Jiao-YanYang Qi
May 11, 2020·Brain Stimulation·Kevin P ChengKip A Ludwig
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Yue WangAilin Luo
Oct 9, 2021·Experimental Neurology·Chanon SrihagulangSiriporn C Chattipakorn

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Methods Mentioned

BETA
X-ray

Software Mentioned

GraphPad
Scion image
Paravision Image Sequence Analysis ( ISA ) Tool
Prism
MATLAB
Bruker

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