Non-L-cell immunophenotype and large tumor size in rectal neuroendocrine tumors are associated with aggressive clinical behavior and worse prognosis

The American Journal of Surgical Pathology
Joo Young KimSeung-Mo Hong

Abstract

According to the 2010 World Health Organization classification, all gastrointestinal neuroendocrine tumors (NETs) are classified as malignant except for L-cell-type (glucagon-like peptide [GLP] and peptide YY [PYY]-producing) NETs. However, L-cell immunophenotype in rectal NETs has not been widely studied previously. Immunohistochemical labeling of L-cell markers with GLP1 and PYY was performed in 208 surgically or endoscopically resected rectal NET cases with tissue microarrays and was compared with clinicopathologic features and patient survival. Rectal NETs with non-L-cell immunophenotype and large tumor size (>1 cm) were associated with increased tumor grading, advanced T category, lymphovascular and perineural invasions, and lymph node and distant metastases (P<0.001, each). Rectal NET patients with non-L-cell phenotype and measuring >1 cm had significantly worse survival outcome than other groups by univariate (P<0.001) and multivariate (P<0.001) analyses. In summary, non-L-cell immunophenotype and large tumor size are associated with increased tumor grading and staging, concurrently indicating that they are independently poor prognostic indicators in rectal NET patients. Therefore, combining L-cell phenotype and tumor si...Continue Reading

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Citations

Apr 30, 2016·Archives of Pathology & Laboratory Medicine·Joo Young Kim, Seung-Mo Hong
Apr 5, 2017·World Journal of Gastroenterology : WJG·Su Bum ParkHyeong Seok Nam
Nov 30, 2016·World Journal of Gastroenterology : WJG·Mi Jung KwonEun Sook Nam
May 21, 2020·International Journal of Molecular Sciences·Aldona Kasprzak, Agnieszka Adamek
Jul 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Louis de MestierPhilippe Ruszniewski
Mar 10, 2021·Pathologica·Marco VolanteMauro Papotti
May 22, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sylvia L AsaUNKNOWN Attendees of the 15th Meeting of the International Pituitary Pathology Club, Istanbul October 2019
May 28, 2021·Endocrine Pathology·Sylvia L AsaOzgur Mete

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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