Non-linear aspects of outer hair cell transduction and the temporary threshold shifts after acoustic trauma

Audiology & Neuro-otology
R B Patuzzi

Abstract

The 200-Hz cochlear microphonic potential (CM) and the compound action potential (CAP) of the auditory nerve evoked by tone-bursts were recorded in the basal turn of the cochlea of anaesthetised guinea pigs, before and after exposure to traumatic high-frequency tones that produce a temporary threshold shift (TTS) in this cochlear region. The drop in CM and the TTS were highly correlated, suggesting that it is the disruption of the outer hair cells generating the CM that causes the TTS. The previously measured rise in endocochlear potential and drop in organ of Corti K+ levels suggest that the TTS is due to a temporary closure of outer hair cell mechanoelectrical transduction (MET) channels, which produces a drop in the mechanical sensitivity of the organ of Corti, due to disruption of the active process provided by outer hair cells. The time course of the onset and recovery of TTS is consistent with a kinetic folding and refolding of MET channels over a time course of hours and days. Mathematical modelling of this putative channel folding suggests that TTS recovery may be accelerated by the presentation of additional sounds during the recovery period. We present electrophysiological data (CM and CAP measurements) showing that t...Continue Reading

Citations

Feb 1, 2006·Ear and Hearing·Donald HendersonBo Hua Hu
Apr 29, 2006·The Journal of the Acoustical Society of America·Yuan ZouAlfred Nuttall
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jinkyung KimJohn S Oghalai
Jul 25, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Rodney C Diaz
Jul 5, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joong Ho AhnJong Woo Chung
Apr 30, 2017·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Lvgang LiuHaipan Wang
Dec 13, 2018·Frontiers in Neuroscience·Haúla Faruk HaiderAgnieszka J Szczepek

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