Abstract
The present study aimed to examine the nonlinear associations between risk factors and mild hypoglycemia in Chinese patients with type 2 diabetes mellitus (T2DM). From May 2013 to August 2013, we conducted a cross sectional survey of 6633 inpatients with T2DM and without severe hypoglycemia, aged 21-77years, from 81 top tertiary hospitals in China. Mild hypoglycemia was defined as having hypoglycemia with symptoms in one month. Binary logistic regression analysis with restricted cubic splines was used to estimate odds ratio curves of non-linear risk factors for mild hypoglycemia. Increasing body mass index was associated with decreasing risk of mild hypoglycemia in a linear manner while age, duration of diabetes, glycated hemoglobin (HbA1c), mean artery pressure and lipids were associated with mild hypoglycemia in non-linear manners. Age ≥40years, duration ≥2years, HbA1c ≥7.0-<11.5% (≥53-<102mmol/mol), triglyceride ≥1.7-<3.6mmol/L, low-density lipoprotein cholesterol (LDL-C) ≥2.6-<4.8mmol/L, and high-density lipoprotein cholesterol (HDL-C) ≥1.2-<4.8mmol/L were associated with increased risks of mild hypoglycemia. Chinese T2DM patients with age≥40years, duration of diabetes ≥2-<6years, HbA1c ≥7.0-<11.5% (≥53-<102mmol/mol), LDL-C...Continue Reading
References
Aug 11, 2000·BMJ : British Medical Journal·I M StrattonR R Holman
Aug 2, 2005·Diabetologia·H C GersteinUNKNOWN HOPE investigators
Nov 25, 2005·Diabetes Care·Nicola N Zammitt, Brian M Frier
Nov 28, 2006·Endocrinology and Metabolism Clinics of North America·Jean-Marc Guettier, Phillip Gorden
Feb 13, 2007·Mayo Clinic Proceedings·George Dailey
Feb 20, 2007·Postgraduate Medical Journal·T Kearney, C Dang
Jul 20, 2007·Annals of Internal Medicine·Shari BolenFrederick L Brancati
Jan 25, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·S A AmielK Jameson
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Jun 10, 2008·The New England Journal of Medicine·UNKNOWN Action to Control Cardiovascular Risk in Diabetes Study GroupWilliam T Friedewald
Aug 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Xilin YangJuliana C N Chan
Dec 6, 2008·Diabetes Research and Clinical Practice·Simon R Heller
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Sep 3, 2010·Heart, Lung & Circulation·Richard J Macisaac, George Jerums
Oct 12, 2010·The New England Journal of Medicine·Sophia ZoungasUNKNOWN ADVANCE Collaborative Group
Nov 8, 2011·Journal of Diabetes and Its Complications·William C DuckworthUNKNOWN Investigators of the VADT
Dec 17, 2011·Diabetes, Obesity & Metabolism·X L YangJ C N Chan
Jun 1, 2012·BMC Endocrine Disorders·Denise E BondsAjay Sood
Jun 16, 2012·Journal of Diabetes and Its Complications·Setareh A WilliamsVivian Fonseca
Aug 10, 2012·Diabetes Care·Yoshifumi SaishoPeter C Butler
Oct 6, 2012·Journal of Diabetes·Makio OkawaShigeru Saito
Oct 19, 2012·BMC Endocrine Disorders·Diethelm TschöpeAnselm K Gitt
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jun 12, 2013·JAMA Internal Medicine·Kristine YaffeUNKNOWN Health ABC Study
Aug 21, 2013·Current Medical Research and Opinion·A H BarnettH Langerman
Oct 4, 2013·Diabetes Care·Berit InksterRebecca M Reynolds
May 16, 2014·Journal of Postgraduate Medicine·S KalraA Maheshwari
Oct 30, 2014·Diabetes Care·UNKNOWN ORIGIN Trial Investigators
Feb 12, 2015·Acta Diabetologica·Carlo B GiordaUNKNOWN HYPOS-1 Study Group of AMD
Apr 8, 2015·Diabetes & Metabolism·L BordierUNKNOWN SFD/SFGG Intergroup
Oct 13, 2015·Diabetes & Metabolism·D SimonC Bradley