Non-linear Dynamical Analysis of Intraspinal Pressure Signal Predicts Outcome After Spinal Cord Injury

Frontiers in Neurology
Suliang ChenSamira Saadoun

Abstract

The injured spinal cord is a complex system influenced by many local and systemic factors that interact over many timescales. To help guide clinical management, we developed a technique that monitors intraspinal pressure from the injury site in patients with acute, severe traumatic spinal cord injuries. Here, we hypothesize that spinal cord injury alters the complex dynamics of the intraspinal pressure signal quantified by computing hourly the detrended fluctuation exponent alpha, multiscale entropy, and maximal Lyapunov exponent lambda. 49 patients with severe traumatic spinal cord injuries were monitored within 72 h of injury for 5 days on average to produce 5,941 h of intraspinal pressure data. We computed the spinal cord perfusion pressure as mean arterial pressure minus intraspinal pressure and the vascular pressure reactivity index as the running correlation coefficient between intraspinal pressure and arterial blood pressure. Mean patient follow-up was 17 months. We show that alpha values are greater than 0.5, which indicates that the intraspinal pressure signal is fractal. As alpha increases, intraspinal pressure decreases and spinal cord perfusion pressure increases with negative correlation between the vascular pressu...Continue Reading

Associated Clinical Trials

References

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Citations

Feb 12, 2019·Scientific Reports·Marjan Mozaffarilegha, S M S Movahed
Jan 10, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Samira Saadoun, Marios C Papadopoulos
Aug 6, 2020·Frontiers in Bioengineering and Biotechnology·Christopher HaleVictor G J Rodgers
Jan 29, 2019·Neural Regeneration Research·Xin ZhangJian-Jun Li
Feb 5, 2021·Topics in Spinal Cord Injury Rehabilitation·Chloe SlocumRoss Zafonte
Jun 1, 2021·Neurosurgery Clinics of North America·Samira Saadoun, Marios C Papadopoulos
Jun 26, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mathias Møller ThygesenMikkel Mylius Rasmussen

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Methods Mentioned

BETA
infrared spectroscopy

Clinical Trials Mentioned

NCT02721615

Software Mentioned

Matlab
LabChart
ICM

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