PMID: 11916507Mar 28, 2002Paper

Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials

Mathematical Biosciences
Davide Verotta, Franziska Schaedeli

Abstract

Human immunodeficiency virus (HIV) dynamics represent a complicated variant of the text-book case of non-linear dynamics: predator-prey interaction. The interaction can be described as naturally reproducing T-cells (prey) hunted and killed by virus (predator). Virus reproduce and increase in number as a consequence of successful predation; this is countered by the production of T-cells and the reaction of the immune system. Multi-drug anti-HIV therapy attempts to alter the natural dynamics of the predator-prey interaction by decreasing the reproductive capability of the virus and hence predation. These dynamics are further complicated by varying compliance to treatment and insurgence of resistance to treatment. When following the temporal progression of viral load in plasma during therapy one observes a short-term (1-12 weeks) decrease in viral load. In the long-term (more than 12 weeks from the beginning of therapy) the reduction in viral load is either sustained, or it is followed by a rebound, oscillations and a new (generally lower than at the beginning of therapy) viral load level. Biomathematicians have investigated these dynamics by means of simulations. However the estimation of the parameters associated with the dynami...Continue Reading

References

Dec 7, 1992·Journal of Theoretical Biology·M A Nowak, R M May
Sep 1, 1991·Mathematical Biosciences·M A Nowak, R M May
Feb 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta, L B Sheiner
Apr 5, 1996·Science·M A Nowak, C R Bangham
Mar 27, 1997·The New England Journal of Medicine·A N Phillips, G D Smith
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·N M FergusonR M Anderson
May 20, 2000·Proceedings. Biological Sciences·L M Wahl, M A Nowak
Mar 10, 2001·IEEE Transactions on Bio-medical Engineering·S AudolyC Cobelli

❮ Previous
Next ❯

Citations

Dec 23, 2004·Journal of Mathematical Biology·H T Banks, D M Bortz
Jan 13, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Chantal Csajka, Davide Verotta
Feb 27, 2007·Journal of Theoretical Biology·O Krakovska, L M Wahl
Dec 14, 2004·Journal of Theoretical Biology·Maria E OriveRobert D Holt
May 25, 2005·Clinical Pharmacokinetics·Jeffrey S BarrettMarc Pfister

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.